CLIP3 blocking peptide

CLIP3 Blocking Peptide

Cat. Num. AAA8243345

• Gene Names: CLIP3; RSNL1; CLIPR59; CLIPR-59
• Reactivity: Human, Mouse, Rat
• Applications: Blocking (BL)
• Purity: >85%
• Synonyms: CLIP3; CLIP3 Blocking Peptide; CLIPR59; CAP-Gly domain-containing linker protein 3; Cytoplasmic linker protein 170-related 59 kDa protein; CLIP-170-related 59 kDa protein; CLIPR-59; CLIP3 blocking peptide

• Host: Synthetic
• Reactivity: Human, Mouse, Rat
• Purity/Purification: >85%
• Form/Format: Lyophilized Powder
• Sequence Length: 547

• Applicable Applications for CLIP3 blocking peptide: Blocking (BL)
• Application Notes: Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
• Quality Control: The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for CLIP3 blocking peptide

The peptide is used to block Anti-CLIP3 Antibody reactivity.

NCBI and Uniprot Product Information

• NCBI GI #: 116241302
• NCBI GeneID: 25999
• UniProt Accession #: Q96DZ5; Q8WWL1; Q96C99; Q9UFT7; A8K0E4
• Molecular Weight: 59,560 Da
• NCBI Official Full Name: CAP-Gly domain-containing linker protein 3
• NCBI Official Synonym Full Names: CAP-Gly domain containing linker protein 3
• NCBI Official Symbol: CLIP3
• NCBI Official Synonym Symbols: RSNL1; CLIPR59; CLIPR-59
• NCBI Protein Information: CAP-Gly domain-containing linker protein 3
• UniProt Protein Name: CAP-Gly domain-containing linker protein 3
• Protein Family: CAP-Gly domain-containing linker protein
• UniProt Gene Name: CLIP3
• UniProt Synonym Gene Names: CLIPR59; CLIP-170-related 59 kDa protein; CLIPR-59
• UniProt Entry Name: CLIP3_HUMAN

NCBI Description

This gene encodes a member of the cytoplasmic linker protein 170 family. Members of this protein family contain a cytoskeleton-associated protein glycine-rich domain and mediate the interaction of microtubules with cellular organelles. The encoded protein plays a role in T cell apoptosis by facilitating the association of tubulin and the lipid raft ganglioside GD3. The encoded protein also functions as a scaffold protein mediating membrane localization of phosphorylated protein kinase B. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]

Uniprot Description

CLIPR-59: Functions as a cytoplasmic linker protein. Involved in TGN-endosome dynamics.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 19q13.12

Cellular Component: cytosol; early endosome membrane; Golgi stack; lipid raft; plasma membrane; recycling endosome membrane; trans-Golgi network; trans-Golgi network membrane

Molecular Function: microtubule binding

Biological Process: cell surface receptor linked signal transduction; fat cell differentiation; negative regulation of microtubule polymerization; peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine; positive regulation of apoptosis; positive regulation of endocytosis; positive regulation of protein amino acid phosphorylation; tumor necrosis factor-mediated signaling pathway