UBA7 blocking peptide

UBA7 Blocking Peptide

Cat. Num. AAA822433

• Gene Names: UBA7; D8; UBE2; UBA1B; UBE1L
• Reactivity: Human
• Applications: Blocking (BL)
• Purity: >85%
• Synonyms: UBA7; UBA7 Blocking Peptide; UBE1L; UBE2; Ubiquitin-like modifier-activating enzyme 7; Ubiquitin-activating enzyme 7; D8; Ubiquitin-activating enzyme E1 homolog; UBA7 blocking peptide

• Host: Synthetic
• Reactivity: Human
• Purity/Purification: >85%
• Form/Format: Lyophilized powder
• Sequence Length: 1012

• Applicable Applications for UBA7 blocking peptide: Blocking (BL)
• Application Notes: Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
• Quality Control: The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for UBA7 blocking peptide

The peptide is used to block Anti-UBA7 Antibody reactivity.

NCBI and Uniprot Product Information

• NCBI GI #: 38045948
• NCBI GeneID: 7318
• NCBI Accession #: NP_003326.2
• NCBI GenBank Nucleotide #: NM_003335.2
• UniProt Accession #: P41226; Q9BRB2
• Molecular Weight: 111,694 Da
• NCBI Official Full Name: ubiquitin-like modifier-activating enzyme 7
• NCBI Official Synonym Full Names: ubiquitin-like modifier activating enzyme 7
• NCBI Official Symbol: UBA7
• NCBI Official Synonym Symbols: D8; UBE2; UBA1B; UBE1L
• NCBI Protein Information: ubiquitin-like modifier-activating enzyme 7; ubiquitin-activating enzyme 7; ubiquitin-activating enzyme-2; UBA7, ubiquitin-activating enzyme E1; ubiquitin-activating enzyme E1 homolog; UBA1, ubiquitin-activating enzyme E1 homolog B; ubiquitin-activating enzyme E1-related protein
• UniProt Protein Name: Ubiquitin-like modifier-activating enzyme 7
• Protein Family: Ubiquitin-like modifier-activating enzyme
• UniProt Gene Name: UBA7
• UniProt Synonym Gene Names: UBE1L; UBE2; Ubiquitin-activating enzyme 7
• UniProt Entry Name: UBA7_HUMAN

NCBI Description

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. [provided by RefSeq, Jul 2008]

Uniprot Description

UBE1L: Activates ubiquitin by first adenylating with ATP its C- terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin- E1 thioester and free AMP. Belongs to the ubiquitin-activating E1 family.

Protein type: Ubiquitin ligase; Ubiquitin conjugating system; EC 6.3.2.19

Chromosomal Location of Human Ortholog: 3p21

Cellular Component: nucleus; cytosol

Molecular Function: ISG15 activating enzyme activity; ubiquitin-protein ligase activity; ubiquitin activating enzyme activity; ATP binding

Biological Process: ISG15-protein conjugation; modification-dependent protein catabolic process; cytokine and chemokine mediated signaling pathway; protein ubiquitination; innate immune response; protein modification process; negative regulation of interferon type I production