SIX3 blocking peptide
SIX3 Blocking Peptide
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the sine oculis homeobox transcription factor family. The encoded protein plays a role in eye development. Mutations in this gene have been associated with holoprosencephaly type 2. [provided by RefSeq, Oct 2009]
Uniprot Description
SIX3: May be involved in visual system development. Defects in SIX3 are the cause of holoprosencephaly type 2 (HPE2). Holoprosencephaly (HPE) is the most common structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability. Belongs to the SIX/Sine oculis homeobox family.
Protein type: Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 2p21
Cellular Component: nucleus
Molecular Function: protein binding; histone deacetylase binding; transcription coactivator activity; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; lens development in camera-type eye; negative regulation of Wnt receptor signaling pathway; epithelial cell maturation; cell proliferation in forebrain; neuroblast differentiation; proximal/distal axis specification; forebrain dorsal/ventral pattern formation; telencephalon regionalization; circadian behavior; regulation of cell proliferation; telencephalon development; negative regulation of neuron differentiation; eye development; visual perception; protein import into nucleus, translocation; pituitary gland development; forebrain anterior/posterior pattern formation; positive regulation of transcription from RNA polymerase II promoter; brain development; negative regulation of transcription, DNA-dependent
Disease: Schizencephaly; Holoprosencephaly 2
Research Articles on SIX3
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Product Notes
The SIX3 six3 (Catalog #AAA824389) is a Blocking Peptide produced from Synthetic and is intended for research purposes only. The product is available for immediate purchase. The SIX3 Blocking Peptide reacts with Human, Mouse, Rat, Chicken, Zebrafish and may cross-react with other species as described in the data sheet. AAA Biotech's SIX3 can be used in a range of immunoassay formats including, but not limited to, Blocking (BL). Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours. Researchers should empirically determine the suitability of the SIX3 six3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SIX3, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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