LYN blocking peptide

LYN (pY192) Blocking Peptide

Cat. Num. AAA8238928

• Gene Names: LYN; JTK8; p53Lyn; p56Lyn
• Reactivity: Human, Mouse, Rat, Bovine, Sheep
• Applications: Blocking (BL)
• Purity: >85%
• Synonyms: LYN; LYN (pY192) Blocking Peptide; JTK8; Tyrosine-protein kinase Lyn; Lck/Yes-related novel protein tyrosine kinase; V-yes-1 Yamaguchi sarcoma viral related oncogene homolog; p53Lyn; p56Lyn; LYN blocking peptide

• Host: Synthetic
• Reactivity: Human, Mouse, Rat, Bovine, Sheep
• Purity/Purification: >85%
• Form/Format: Lyophilized powder
• Sequence Length: 491

• Applicable Applications for LYN blocking peptide: Blocking (BL)
• Quality Control: The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
• Directions for Use: Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for LYN blocking peptide

The peptide is used to block Anti-LYN (pY192) Antibody reactivity.

NCBI and Uniprot Product Information

• NCBI GI #: 162287326
• NCBI GeneID: 4067
• NCBI Accession #: NP_001104567.1
• NCBI GenBank Nucleotide #: NM_001111097.2
• UniProt Accession #: P07948; A0AVQ5
• Molecular Weight: 56,033 Da
• NCBI Official Full Name: tyrosine-protein kinase Lyn isoform B
• NCBI Official Synonym Full Names: LYN proto-oncogene, Src family tyrosine kinase
• NCBI Official Symbol: LYN
• NCBI Official Synonym Symbols: JTK8; p53Lyn; p56Lyn
• NCBI Protein Information: tyrosine-protein kinase Lyn
• UniProt Protein Name: Tyrosine-protein kinase Lyn
• Protein Family: Tyrosine-protein kinase
• UniProt Gene Name: LYN
• UniProt Synonym Gene Names: JTK8
• UniProt Entry Name: LYN_HUMAN

NCBI Description

This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

Uniprot Description

LYN: a tyrosine kinase of the Src family that plays a role in B cell antigen-receptor signaling.

Protein type: Protein kinase, tyrosine (non-receptor); Protein kinase, TK; Kinase, protein; Oncoprotein; EC 2.7.10.2; TK group; Src family

Chromosomal Location of Human Ortholog: 8q13

Cellular Component: Golgi apparatus; mitochondrial crista; extrinsic to internal side of plasma membrane; mast cell granule; perinuclear region of cytoplasm; cytoplasm; postsynaptic density; plasma membrane; mitochondrial intermembrane space; nucleus; cytosol; lipid raft

Molecular Function: integrin binding; protein binding; enzyme binding; protein-tyrosine kinase activity; ubiquitin protein ligase binding; platelet-derived growth factor receptor binding; non-membrane spanning protein tyrosine kinase activity; phosphoprotein binding; receptor signaling protein tyrosine kinase activity; glycosphingolipid binding; SH3 domain binding; ATP binding; receptor binding

Biological Process: regulation of mast cell degranulation; negative regulation of MAP kinase activity; central nervous system development; viral reproduction; response to toxin; positive regulation of B cell receptor signaling pathway; response to organic cyclic substance; protein amino acid phosphorylation; response to carbohydrate stimulus; regulation of B cell apoptosis; B cell receptor signaling pathway; erythrocyte differentiation; oligodendrocyte development; tolerance induction to self antigen; response to drug; platelet activation; negative regulation of immune response; response to sterol depletion; immune response-regulating cell surface receptor signaling pathway; response to amino acid stimulus; regulation of erythrocyte differentiation; histamine secretion by mast cell; T cell costimulation; leukocyte migration; cytokine secretion; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of mast cell activation; axon guidance; regulation of cytokine secretion; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; response to hormone stimulus; negative regulation of B cell proliferation; signal transduction; response to insulin stimulus; regulation of cytokine production; negative regulation of cell proliferation; regulation of cell adhesion mediated by integrin; platelet degranulation; negative regulation of protein amino acid phosphorylation; B cell homeostasis; positive regulation of cell proliferation; ephrin receptor signaling pathway; lipopolysaccharide-mediated signaling pathway; Fc receptor mediated inhibitory signaling pathway; response to axon injury; Fc receptor mediated stimulatory signaling pathway; inflammatory response; regulation of B cell receptor signaling pathway; regulation of protein amino acid phosphorylation; negative regulation of myeloid leukocyte differentiation; negative regulation of toll-like receptor 2 signaling pathway; positive regulation of phosphoinositide 3-kinase activity; positive regulation of cell motility; regulation of release of sequestered calcium ion into cytosol; positive regulation of tyrosine phosphorylation of STAT protein; regulation of inflammatory response; negative regulation of toll-like receptor 4 signaling pathway; cellular response to extracellular stimulus; innate immune response; blood coagulation; response to DNA damage stimulus; positive regulation of cell migration