PPP2R5D blocking peptide

PPP2R5D Blocking Peptide

Cat. Num. AAA8240750

• Gene Names: PPP2R5D; B56D; MRD35
• Reactivity: Human, Bovine, Monkey, Rabbit
• Applications: Blocking (BL)
• Purity: >85%
• Synonyms: PPP2R5D; PPP2R5D Blocking Peptide; Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform; PP2A B subunit isoform B'-delta; PP2A B subunit isoform B56-delta; PP2A B subunit isoform PR61-delta; PP2A B subunit isoform R5-delta; PPP2R5D blocking peptide

• Host: Synthetic
• Reactivity: Human, Bovine, Monkey, Rabbit
• Purity/Purification: >85%
• Form/Format: Lyophilized powder
• Sequence Length: 451

• Applicable Applications for PPP2R5D blocking peptide: Blocking (BL)
• Quality Control: The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
• Directions for Use: Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for PPP2R5D blocking peptide

The peptide is used to block Anti-PPP2R5D Antibody reactivity.

NCBI and Uniprot Product Information

• NCBI GI #: 394582140
• NCBI GeneID: 5528
• NCBI Accession #: NP_001257405.1
• NCBI GenBank Nucleotide #: NM_001270476.1
• UniProt Accession #: Q14738; O00494; O00696; Q15171; Q5TC39; A8K3I9; B5BUA6
• Molecular Weight: 58,453 Da
• NCBI Official Full Name: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform 4
• NCBI Official Synonym Full Names: protein phosphatase 2, regulatory subunit B', delta
• NCBI Official Symbol: PPP2R5D
• NCBI Official Synonym Symbols: B56D; MRD35
• NCBI Protein Information: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
• UniProt Protein Name: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
• Protein Family: Serine/threonine-protein phosphatase
• UniProt Gene Name: PPP2R5D
• UniProt Entry Name: 2A5D_HUMAN

NCBI Description

The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a delta isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Description

PPP2R5D: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with SGOL1. By retinoic acid; in neuroblastoma cell lines. Isoform Delta-2 is widely expressed. Isoform Delta-1 is highly expressed in brain. Belongs to the phosphatase 2A regulatory subunit B56 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein phosphatase, regulatory subunit; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 6p21.1

Cellular Component: nucleoplasm; protein phosphatase type 2A complex; cytosol; nucleus

Molecular Function: protein binding; protein phosphatase type 2A regulator activity; protein serine/threonine phosphatase activity

Biological Process: nervous system development; glycolysis; nerve growth factor receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; stress-activated MAPK cascade; glucose metabolic process; pathogenesis; toll-like receptor 3 signaling pathway; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor 5 signaling pathway; dephosphorylation; regulation of catalytic activity; carbohydrate metabolic process; energy reserve metabolic process; toll-like receptor signaling pathway; innate immune response; toll-like receptor 9 signaling pathway; toll-like receptor 4 signaling pathway

Disease: Mental Retardation, Autosomal Dominant 35