BAGE5 Blocking Peptide | BAG5 blocking peptide

BAGE5 Blocking Peptide

Cat. Num. AAA822811

• Gene Names: BAG5; BAG-5
• Reactivity: Human, Bovine, Monkey
• Applications: Blocking (BL)
• Purity: >85%
• Synonyms: BAGE5; BAGE5 Blocking Peptide; KIAA0873; BAG family molecular chaperone regulator 5; BAG-5; Bcl-2-associated athanogene 5; BAG5 blocking peptide

• Host: Synthetic
• Reactivity: Human, Bovine, Monkey
• Purity/Purification: >85%
• Form/Format: Lyophilized powder
• Sequence Length: 447

• Applicable Applications for BAG5 blocking peptide: Blocking (BL)
• Application Notes: Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
• Quality Control: The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for BAG5 blocking peptide

The peptide is used to block Anti-BAGE5 Antibody reactivity.

NCBI and Uniprot Product Information

• NCBI GI #: 62548854
• NCBI GeneID: 9529
• NCBI Accession #: NP_001015048.1
• NCBI GenBank Nucleotide #: NM_001015048.2
• UniProt Accession #: Q9UL15; O94950; Q86W59
• Molecular Weight: 56,027 Da
• NCBI Official Full Name: BAG family molecular chaperone regulator 5 isoform b
• NCBI Official Synonym Full Names: BCL2-associated athanogene 5
• NCBI Official Symbol: BAG5
• NCBI Official Synonym Symbols: BAG-5
• NCBI Protein Information: BAG family molecular chaperone regulator 5; bcl-2-associated athanogene 5; BAG-family molecular chaperone regulator-5
• UniProt Protein Name: BAG family molecular chaperone regulator 5
• Protein Family: BAG family molecular chaperone regulator
• UniProt Gene Name: BAG5
• UniProt Synonym Gene Names: KIAA0873; BAG-5
• UniProt Entry Name: BAG5_HUMAN

NCBI Description

The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

BAG5: Inhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2. May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 14q32.33

Cellular Component: mitochondrion; membrane; perinuclear region of cytoplasm; inclusion body; nucleus

Molecular Function: protein binding; chaperone binding; ubiquitin protein ligase binding; protein kinase binding

Biological Process: protein folding; negative regulation of ubiquitin-protein ligase activity; negative regulation of protein ubiquitination; negative regulation of proteasomal ubiquitin-dependent protein catabolic process