SWI/SNF chromatin-remodeling complex subunit SWI1 (ADR6) Recombinant Protein | ADR6 recombinant protein
Recombinant Saccharomyces cerevisiae SWI/SNF chromatin-remodeling complex subunit SWI1 (ADR6) , partial
NCBI and Uniprot Product Information
Uniprot Description
Involved in transcriptional activation. Component of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, which is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.Miscellaneous[SWI+] is the prion form of SWI1 (PubMed:18362884). [SWI+] is the result of a conformational change of the cellular SWI1 protein that becomes self-propagating and infectious. This conformational change generates a form of SWI1 that assembles into amyloid fibrils (PubMed:20679490). [SWI+]-aggregates sequester soluble SWI1, resulting in reduced growth on carbon sources other than glucose, reminiscent of a partial loss of function of the SWI/SNF chromatin-remodeling complex. [SWI+] can be cured by GdnHCl and by deletion of the molecular chaperone HSP104, which is required for [SWI+] propagation (PubMed:18362884). [SWI+] propagation is highly dependent upon the action of members of the Hsp70 molecular chaperone system, specifically the Hsp70 SSA, two of its J-protein co-chaperones, SIS1 and YDJ1, and the nucleotide exchange factors of the Hsp110 family (SSE1/2). Both under- and overexpression of components of this system initiate rapid loss of the prion from the cell population. It is speculated that prion properties of transcription factors may generate an optimized phenotypic heterogeneity that buffers yeast populations against diverse environmental insults (PubMed:21379326).
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Product Notes
The ADR6 swi1 (Catalog #AAA1181428) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "SWI/SNF chromatin-remodeling complex subunit SWI1 (ADR6), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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