Thrombin-like enzyme gabonase Recombinant Protein | SVTLE recombinant protein
Recombinant Bitis gabonica Thrombin-like enzyme gabonase
NCBI and Uniprot Product Information
Uniprot Description
Function: Thrombin-like snake venom serine protease. Releases both fibrinopeptides A and B from fibrinogen (FGA and FGB) to form fibrin clots. Also activates factor XIII (F13A). The activity of the enzyme is stabilized by calcium ion.
Catalytic activity: Preferential cleavage: Arg-|-Xaa bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
Enzyme regulation: Inhibited by PMSF, but not by heparin, hirudin and antithrombin III. Ref.1
Subunit structure: Monomer. Ref.1
Subcellular location: Secreted.
Tissue specificity: Expressed by the venom gland.
Post-translational modification: Glycosylated.Contains five disulfide bonds
Probable.
Sequence similarities: Belongs to the peptidase S1 family. Snake venom subfamily.Contains 1 peptidase S1 domain.
Biophysicochemical propertiesKinetic parameters:KM=0.12 mM for Tosyl-L-arginine methyl ester (TAME) Ref.1KM=0.13 mM for Tosyl-Gly-Pro-Arg 4-nitroanilideKM=0.82 mM for H-D-Pro-hexahydrotyrosyl-Arg 4-nitroanilideKM=0.88 mM for H-D-Hexahydrotyrosyl-Ala-Arg 4-nitroanilideKM=2.72 mM for Tosyl-Gly-Pro-Lys 4-nitroanilideKM=3.4 mM for H-D-Phenylglycine-Phe-Arg 4-nitroanilideTemperature dependence:Optimum temperature is 30 degrees Celsius with tosyl-Arg-methyl ester (TAME) as substrate and 37 degrees Celsius with natural substrates.
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Product Notes
The Thrombin-like enzyme gabonase svtle (Catalog #AAA1215886) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-19aa; Full Length. The amino acid sequence is listed below: VVGGAECKID GHRCLALLY. It is sometimes possible for the material contained within the vial of "Thrombin-like enzyme gabonase, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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