Thrombin-like enzyme BpSP-1 Recombinant Protein | SVTLE BpSP-1 recombinant protein
Recombinant Bothropoides pauloensis Thrombin-like enzyme BpSP-1
NCBI and Uniprot Product Information
Uniprot Description
Function: Thrombin-like enzyme that has high clotting activity upon bovine and human plasma. Has also fibrinogenoltic activity by rapidly hydrolyzing Aalpha chain of fibrinogen (FGA), and partially consumes Bbeta chain (FGB). Has high catalytic activity upon substrates such as TAME, and specific substrates for thrombin S-2238 and S-2288. Also hydrolyzes specific substrates for kallikrein (S-2266 and S-2302), however, no release of kinin upon plasma has been determined. When administered intraperitoneally in mice, causes defibrinogenation, making the plasma incoagulable.
Enzyme regulation: Inhibited PMSF, benzamidine, leupeptin, and Cu2+. Ref.1
Subcellular location: Secreted.
Tissue specificity: Expressed by the venom gland.
Post-translational modification: N-glycosylated. Contains sialic acid residues. Ref.1
Miscellaneous: Does not act on the gamma chain of fibrinogen. Does not act upon factor Xa (F10) and plasmin substrates. Does not induce hemorrhage, myotoxicity or edema (Ref.1).
Sequence similarities: Belongs to the peptidase S1 family. Snake venom subfamily.Contains 1 peptidase S1 domain.
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Product Notes
The Thrombin-like enzyme BpSP-1 svtle bpsp-1 (Catalog #AAA1133766) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-15aa; full length protein. The amino acid sequence is listed below: VIGGDECDIN EHPFL. It is sometimes possible for the material contained within the vial of "Thrombin-like enzyme BpSP-1, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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