Platelet-aggregating proteinase PA-BJ Recombinant Protein | SVSP recombinant protein
Recombinant Bothrops jararaca Platelet-aggregating proteinase PA-BJ
NCBI and Uniprot Product Information
Uniprot Description
Snake venom serine protease that induces platelet aggregation through activation of protease-activated platelet receptors (PAR1/F2R and PAR4/F2RL3). On F2R, the cleavage occurs at Arg41-Ser42 (like thrombin cleavage), and Arg46-Asn47. In normal condition of hemostasis, the cleavage of the Arg41-Ser42 bond liberates a new N-terminus that functions as an agonist. However after envenomation, the cleavage of Arg46-Asn47 bond degrades this potential agonist. This may explain why the snake protease is less potent than thrombin in causing platelet aggregation and release reaction. On F2RL3, a thrombin-like activity has also been proven by calcium release from lung fibroblasts transfected with this receptor. Possesses amidolytic activities.
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Product Notes
The Platelet-aggregating proteinase PA-BJ svsp (Catalog #AAA1198221) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 6-237, Full length protein. The amino acid sequence is listed below: VVGGRPCKIN VHRSLVLLYN SSSLLCSGTL INQEWVLTAA HCDSKNFKMK LGVHSIKIRN KNERTRHPKE KFICPNRKKD DVLDKDIMLI RLNRPVSNSE HIAPLSLPSS PPSVGSVCYV MGWGKISSTK ETYPDVPHCA KINILDHAVC RAAYTWWPAT STTLCAGILQ GGKDTCEGDS GGPLICNGLQ GIVSGGGNPC GQPRKPALYT KVFDYLPWIE SIIAGTTTAT CP. It is sometimes possible for the material contained within the vial of "Platelet-aggregating proteinase PA-BJ, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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