Mouse suppressor of zeste 12 homolog (Drosophila) ELISA Kit | SUZ12 elisa kit
Mouse Polycomb protein SUZ12, SUZ12 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a core component of the polycomb repressive complex 2 (PRC2) that also includes, at least, embryonic ectoderm development protein (EED) and enhancer of zeste homolog 1 or 2 (EZH1 or EZH2). Through the methyltransferase activity of EZH1 or EZH2, the PRC2 complex methylates Lys9 and Lys27 of histone 3 and Lys26 of histone 1, leading to recruitment of the PRC1 complex, histone 2A ubiquitylation and transcriptional repression of the target genes. This gene product is essential for the activity and integrity of the PRC2 complex, and is required for X chromosome inactivation, stem cell maintenance and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]
Uniprot Description
SUZ12: a zinc finger protein. A breakpoint translocation of the cognate gene with JAZF1 has been reported in endometrial stromal sarcoma.
Protein type: Oncoprotein; C2H2-type zinc finger protein; Transcription factor
Cellular Component: sex chromatin; ESC/E(Z) complex; nucleolus; chromosome; nucleus
Molecular Function: histone methyltransferase activity; protein binding; sequence-specific DNA binding; RNA binding; metal ion binding; chromatin binding; methylated histone residue binding
Biological Process: histone methylation; negative regulation of chemokine production; negative regulation of cell differentiation; transcription, DNA-dependent; regulation of transcription, DNA-dependent; histone ubiquitination; positive regulation of cell proliferation; negative regulation of tyrosine phosphorylation of Stat3 protein; negative regulation of transcription from RNA polymerase II promoter; chromatin modification; negative regulation of epithelial cell proliferation
Research Articles on SUZ12
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Product Notes
The Mouse SUZ12 suz12 (Catalog #AAA9341336) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9341336 ELISA Kit recognizes Mouse SUZ12. It is sometimes possible for the material contained within the vial of "suppressor of zeste 12 homolog (Drosophila), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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