Mouse suppressor of variegation 3-9 homolog 1 (Drosophila) ELISA Kit | SUV39H1 elisa kit
Mouse Histone-lysine N-methyltransferase SUV39H1, SUV39H1 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
SUV39H1: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys- 9' as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. Interacts with H3 and H4 histones. Interacts with GFI1B, DNMT3B, CBX1, CBX4, KIAA1967/DBC1, MBD1, RUNX1, RUNX3, MYOD1, SMAD5 and RB1. Interacts with SBF1 through the SET domain. Interacts with HDAC1 and HDAC2 through the N-terminus and associates with the core histone deacetylase complex composed of HDAC1, HDAC2, RBBP4 and RBBP7. Component of the eNoSC complex, composed of SIRT1, SUV39H1 and RRP8. In case of infection, interacts with HTLV-1 Tax protein, leading to abrogate Tax transactivation of HTLV-1 LTR. Interacts (via SET domain) with MECOM; enhances MECOM transcriptional repression activity. Inhibited by S-adenosyl-L-homocysteine. Negatively regulated by KIAA1967/DBC1. Belongs to the histone-lysine methyltransferase family. Suvar3-9 subfamily.
Protein type: Methyltransferase; Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; Methyltransferase, protein lysine
Cellular Component: heterochromatin; chromatin silencing complex; nuclear heterochromatin; chromosome; nucleus; chromosome, pericentric region
Molecular Function: transferase activity; methyltransferase activity; histone methyltransferase activity; protein binding; zinc ion binding; metal ion binding; S-adenosylmethionine-dependent methyltransferase activity; histone lysine N-methyltransferase activity (H3-K9 specific); protein N-terminus binding; protein methyltransferase activity; histone-lysine N-methyltransferase activity
Biological Process: methylation; chromatin silencing at rDNA; protein amino acid methylation; transcription, DNA-dependent; chromatin silencing; rhythmic process; chromatin modification; negative regulation of transcription from RNA polymerase II promoter; cell cycle; peptidyl-lysine methylation; regulation of transcription, DNA-dependent; negative regulation of circadian rhythm; negative regulation of transcription, DNA-dependent; cell differentiation; DNA packaging; response to DNA damage stimulus; rRNA processing; histone H3-K9 methylation
Research Articles on SUV39H1
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Product Notes
The Mouse SUV39H1 suv39h1 (Catalog #AAA9335479) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9335479 ELISA Kit recognizes Mouse SUV39H1. It is sometimes possible for the material contained within the vial of "suppressor of variegation 3-9 homolog 1 (Drosophila), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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