Sulfite Oxidase Recombinant Protein | SUOX recombinant protein

Recombinant Sulfite Oxidase (SUOX)

Cat. Num. AAA2031545

• Applications: SDS-Page, Western Blot, ELISA, Immunoprecipitation
• Purity: >90%
• Synonyms: Sulfite Oxidase; Recombinant Sulfite Oxidase (SUOX); SUOX recombinant protein

• Host: Host: E Coli; Source: Prokaryotic expression
• Purity/Purification: >90%
• Form/Format: Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
• Sequence Length: 488

• Applicable Applications for SUOX recombinant protein: SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)
• Predicted Molecular Mass: 29.0kDa
• Accurate Molecular Mass (KD): 29kDa
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Expression System: Prokaryotic expression
• Tag: two N-terminal Tags, His-tag and S-tag
• Organism Species: Bos taurus; Bovine (Cattle)
• Fragment: Pro177~Lys403
• Usage: Reconstitute in sterile PBS, pH7.2-pH7.4.
• Preparation and Storage: Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.; Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. The loss of this protein is less than 5% within the expiration date under appropriate storage condition.

SDS-Page

NCBI and Uniprot Product Information

• NCBI GI #: 508502
• NCBI GeneID: 6821
• Molecular Weight: 60,283 Da
• NCBI Official Full Name: sulfite oxidase
• NCBI Official Synonym Full Names: sulfite oxidase
• NCBI Official Symbol: SUOX
• NCBI Protein Information: sulfite oxidase, mitochondrial
• UniProt Protein Name: Sulfite oxidase, mitochondrial
• Protein Family: Sulfite oxidase
• UniProt Gene Name: SUOX
• UniProt Entry Name: SUOX_HUMAN

NCBI Description

Sulfite oxidase is a homodimeric protein localized to the intermembrane space of mitochondria. Each subunit contains a heme domain and a molybdopterin-binding domain. The enzyme catalyzes the oxidation of sulfite to sulfate, the final reaction in the oxidative degradation of the sulfur amino acids cysteine and methionine. Sulfite oxidase deficiency results in neurological abnormalities which are often fatal at an early age. Alternative splicing results in multiple transcript variants encoding identical proteins. [provided by RefSeq, Jul 2008]

Uniprot Description

SUOX: Defects in SUOX are the cause of isolated sulfite oxidase deficiency (ISOD); also known as sulfocysteinuria. ISOD is characterized by neurological abnormalities including multicystic leukoencephalopathy with brain atrophy. Patients often suffer from seizures. Often leads to death at an early age.

Protein type: Energy Metabolism - sulfur; EC 1.8.3.1; Mitochondrial; Oxidoreductase

Chromosomal Location of Human Ortholog: 12q13.2

Cellular Component: mitochondrial matrix; mitochondrial intermembrane space

Molecular Function: molybdopterin cofactor binding; electron carrier activity; molybdenum ion binding; heme binding; sulfite oxidase activity

Biological Process: sulfur amino acid metabolic process; sulfur amino acid catabolic process

Disease: Sulfocysteinuria