SUMO2/3 Blocking Peptide | SUMO3 (HGNC:11124) blocking peptide

SUMO2/3 Antibody (C-term) Blocking Peptide

• Gene Names: SUMO3; SMT3A; Smt3B; SMT3H1; SUMO-3
• Synonyms: SUMO2/3; SUMO2/3 Antibody (C-term) Blocking Peptide; Small ubiquitin-related modifier 3; SUMO-3; SMT3 homolog 1; SUMO-2; Ubiquitin-like protein SMT3A; Smt3A; SUMO3; SUMO3 (HGNC:11124) blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human SUMO2/3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
• Sequence Length: 103

• Cellular Location: Cytoplasm. Nucleus. Nucleus, PML body
• Tissue Location: Expressed predominantly in liver.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for SUMO3 (HGNC:11124) blocking peptide

Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4.

NCBI and Uniprot Product Information

• NCBI GI #: 23503102
• NCBI GeneID: 6612
• UniProt Accession #: P55854; Q53HI9; Q6FGD4; Q9BWR4; B2R5X4; B4DUW4
• Molecular Weight: 15,768 Da
• NCBI Official Full Name: Small ubiquitin-related modifier 3
• NCBI Official Synonym Full Names: small ubiquitin-like modifier 3
• NCBI Official Symbol: SUMO3
• NCBI Official Synonym Symbols: SMT3A; Smt3B; SMT3H1; SUMO-3
• NCBI Protein Information: small ubiquitin-related modifier 3
• UniProt Protein Name: Small ubiquitin-related modifier 3
• UniProt Gene Name: SUMO3
• UniProt Synonym Gene Names: Smt3A
• UniProt Entry Name: SUMO3_HUMAN

NCBI Description

This gene encodes a member of the small ubiquitin-related modifier (SUMO) family of eukaryotic proteins. The encoded protein is covalently conjugated to other proteins via a post-translation modification known as sumoylation. Sumoylation may play a role in a wide variety of cellular processes, including nuclear transport, DNA replication and repair, mitosis, transcriptional regulation, and signal transduction. Alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Feb 2014]

Uniprot Description

SUMO3: Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. Covalently attached to a number of proteins. Interacts with USP25 (via ts SIM domain); the interaction sumoylates USP25 and inhibits its ubiquitin hydrolyzing activity. Interacts with SAE2 and UBE2I. Expressed predominantly in liver. Belongs to the ubiquitin family. SUMO subfamily.

Protein type: Ubiquitin-like modifier

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: kinetochore; nucleoplasm; nucleus

Molecular Function: protein binding; protein tag

Biological Process: protein sumoylation