Hamster Syntaxin 1A, Brain ELISA Kit | STX1A elisa kit

Hamster Syntaxin 1A, Brain ELISA Kit

Cat. Num. AAA93454

• Gene Names: STX1A; STX1; HPC-1; P35-1; SYN1A
• Reactivity: Hamster
• Synonyms: Syntaxin 1A; Brain; Hamster Syntaxin 1A; Brain ELISA Kit; STX1A elisa kit

• Reactivity: Hamster
• Sequence Length: 288

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 4759182
• NCBI GeneID: 6804
• NCBI Accession #: NP_004594.1
• NCBI GenBank Nucleotide #: NM_004603.3
• UniProt Accession #: Q16623; O15447; O15448; Q12936; Q75MD9; Q7Z5K3; Q9BPZ6
• Molecular Weight: 33,023 Da
• NCBI Official Full Name: syntaxin-1A isoform 1
• NCBI Official Synonym Full Names: syntaxin 1A (brain)
• NCBI Official Symbol: STX1A
• NCBI Official Synonym Symbols: STX1; HPC-1; P35-1; SYN1A
• NCBI Protein Information: syntaxin-1A; neuron-specific antigen HPC-1
• UniProt Protein Name: Syntaxin-1A
• Protein Family: Syntaxin
• UniProt Gene Name: STX1A
• UniProt Synonym Gene Names: STX1
• UniProt Entry Name: STX1A_HUMAN

NCBI Description

This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

Uniprot Description

STX1A: a type IV membrane protein involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A. Three splice variant isoforms have been described.

Protein type: Vesicle; Membrane protein, integral

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: SNARE complex; synaptic vesicle; neuron projection; synaptic vesicle membrane; integral to membrane; extracellular region; plasma membrane; actomyosin; endomembrane system; cytosol; cell junction; secretory granule

Molecular Function: protein binding, bridging; protein domain specific binding; SNAP receptor activity; myosin binding; protein N-terminus binding; calcium-dependent protein binding; ATP-dependent protein binding; protein binding; SNARE binding; chloride channel inhibitor activity; protein heterodimerization activity; myosin head/neck binding; calcium channel inhibitor activity; glycoprotein binding; kinase binding

Biological Process: response to gravity; neurotransmitter secretion; pathogenesis; positive regulation of neurotransmitter secretion; calcium ion-dependent exocytosis; synaptic vesicle fusion to presynaptic membrane; synaptic transmission; intracellular protein transport; cellular protein metabolic process; vesicle docking; glutamate secretion; energy reserve metabolic process; regulation of insulin secretion; synaptic vesicle docking during exocytosis; positive regulation of exocytosis; secretion by cell