Human STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae) ELISA Kit | STT3B elisa kit
Human Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B, STT3B ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a catalytic subunit of a protein complex that transfers oligosaccharides onto asparagine residues. Defects in this gene are a cause of congenital disorder of glycosylation Ix (CDG1X). [provided by RefSeq, Jun 2014]
Uniprot Description
STT3B: Catalytic component of oligosaccharyltransferase (OST) oligosaccharyltransferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X- Ser/Thr consensus motif in nascent polypeptide chains. N- glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). STT3B is present in a small subset of OST complexes and mediates both cotranslational and post-translational N-glycosylation of target proteins: STT3B-containing complexes are required for efficient cotranslational glycosylation and while they are less competent than STT3A-containing complexes for cotranslational glycosylation, they have the ability to mediate glycosylation of some nascent sites that are not accessible for STT3A. STT3B-containing complexes also act post-translationally and mediate modification of skipped glycosylation sites in unfolded proteins. Plays a role in ER-associated degradation (ERAD) pathway that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins by mediating N- glycosylation of unfolded proteins, which are then recognized by the ERAD pathway and targeted for degradation. Mediates glycosylation of the disease variant AMYL-TTR 'Asp-38' of TTR at 'Asn-118', leading to its degradation. Belongs to the STT3 family.
Protein type: EC 2.4.99.18; Glycan Metabolism - N-glycan biosynthesis; Membrane protein, multi-pass; Membrane protein, integral; Transferase
Chromosomal Location of Human Ortholog: 3p23
Cellular Component: membrane; endoplasmic reticulum; oligosaccharyl transferase complex; integral to membrane
Molecular Function: dolichyl-diphosphooligosaccharide-protein glycotransferase activity
Biological Process: ER-associated protein catabolic process; co-translational protein modification; protein amino acid N-linked glycosylation via asparagine; glycoprotein catabolic process; post-translational protein modification; response to unfolded protein
Disease: Congenital Disorder Of Glycosylation, Type Ix
Research Articles on STT3B
Similar Products
Product Notes
The Human STT3B stt3b (Catalog #AAA9317174) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9317174 ELISA Kit recognizes Human STT3B. It is sometimes possible for the material contained within the vial of "STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
