STE20-related kinase adapter protein alpha (STRADA) Recombinant Protein | STRADA recombinant protein
Recombinant Chicken STE20-related kinase adapter protein alpha (STRADA)
Gene Names
STRADA; LYK5
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
STE20-related kinase adapter protein alpha (STRADA); Recombinant Chicken STE20-related kinase adapter protein alpha (STRADA); STRADA recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
1-389, Full length protein
Sequence
MSNFLPDSSCYELLTIIGRGFEDLMVVNLARYKPSGEYVTVRRVNLEACTNEMVTFLQGELHVSKLFNHPNIVPYKATFIADNELWVVTSFMAYGSAKDLICTHFMDGMSELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMINHGQRLKVVHDFPKYSIKVLPWLSPEVLQQNLQGYDAKSDIYSIGITACELANGHVPFKDMPSTQMLLEKLNGTVPCLLDTTTIPADELTMKTSRSSANYGLGESTAVSNVRAANGESTLHPYLRTFSSCFHNFVGQCLQRNPDFRPSAGALLNHPFFKQIKRRASEALPELLRPVTPITNFEGTRPQDPSGILGWCQTWSSWMWMTGNSRKTKTALGSGGAFWTL
Sequence Length
389
Species
Chicken
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Related Product Information for STRADA recombinant protein
This protein contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a pseudokinase . The protein forms a heterotrimeric complex with serine
threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known.
threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
43,397 Da
NCBI Official Full Name
STE20-related kinase adapter protein alpha
NCBI Official Synonym Full Names
STE20-related kinase adaptor alpha
NCBI Official Symbol
STRADA
NCBI Official Synonym Symbols
LYK5
NCBI Protein Information
STE20-related kinase adapter protein alpha
UniProt Protein Name
STE20-related kinase adapter protein alpha
Protein Family
UniProt Gene Name
STRADA
UniProt Synonym Gene Names
STRAD; STRAD alpha
Uniprot Description
Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation ().
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Product Notes
The STRADA strada (Catalog #AAA1336700) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-389, Full length protein. The amino acid sequence is listed below: MSNFLPDSSC YELLTIIGRG FEDLMVVNLA RYKPSGEYVT VRRVNLEACT NEMVTFLQGE LHVSKLFNHP NIVPYKATFI ADNELWVVTS FMAYGSAKDL ICTHFMDGMS ELAIAYILQG VLKALDYIHH MGYVHRSVKA SHILISVDGK VYLSGLRSNL SMINHGQRLK VVHDFPKYSI KVLPWLSPEV LQQNLQGYDA KSDIYSIGIT ACELANGHVP FKDMPSTQML LEKLNGTVPC LLDTTTIPAD ELTMKTSRSS ANYGLGESTA VSNVRAANGE STLHPYLRTF SSCFHNFVGQ CLQRNPDFRP SAGALLNHPF FKQIKRRASE ALPELLRPVT PITNFEGTRP QDPSGILGWC QTWSSWMWMT GNSRKTKTAL GSGGAFWTL. It is sometimes possible for the material contained within the vial of "STE20-related kinase adapter protein alpha (STRADA), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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