STK36 recombinant protein

STK36, Active

Cat. Num. AAA517595

• Gene Names: STK36; FU
• Applications: Western Blot
• Synonyms: STK36; Active; FU; DKFZp434N0223; STK36 recombinant protein

• Host: Sf9 insect cells
• Form/Format: Recombinant protein stored in 50mM Tris-HCl, pH7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

• Applicable Applications for STK36 recombinant protein: Kinase Assay, Western Blot (WB)
• Tag: GST
• Species: Human
• Preparation and Storage: Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Activity

(Specific Activity: Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.)

SDS-Page

(Purity: Sample Purity Data. For specific information on a given lot, see related technical data sheet.)

Related Product Information for STK36 recombinant protein

Recombinant human STK36 (1-457) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The STK36 gene accession number is BC026158.
STK36 is a member of the serine/threonine kinase family and is similar to a protein which plays a key role in the Hedgehog signaling pathway. STK36 is a positive regulator of the GLI zinc-finger transcription factors and controls the activity of GLI1 and GLI2 by opposing the effect of SUFU (1). STK36 is highly expressed in fetal lung and adult testis (2). STK36 is a target for the treatment of gastrointestinal cancers since the Hedgehog signaling pathway is frequently activated in certain kinds of gastrointestinal cancers. Defects in the STK36 gene may lead to congenital hydrocephalus, possibly due to a functional defect in motile cilia.

Product Categories/Family for STK36 recombinant protein

Protein Kinases; Cardiovascular Disease; ERK/MAPK Pathway; Neurobiology; PKA/PKC Pathway; Ser/Thr Kinases

References

1. Murone, M. et.al: Gli regulation by the opposing activities of Fused and Suppressor of Fused. Nature Cell Biol. 2: 310-3112, 2000.
2. Nagase, T. et.al: Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 6: 337-345, 1999.

NCBI and Uniprot Product Information

• NCBI GI #: 34191803
• NCBI GeneID: 27148
• Molecular Weight: 87.0 kDa
• NCBI Official Full Name: Homo sapiens serine/threonine kinase 36, fused homolog (Drosophila), mRNA
• NCBI Official Synonym Full Names: serine/threonine kinase 36
• NCBI Official Symbol: STK36
• NCBI Official Synonym Symbols: FU
• NCBI Protein Information: serine/threonine-protein kinase 36
• Protein Family: Serine/threonine-protein kinase

NCBI Description

This gene encodes a member of the serine/threonine kinase family of enzymes. This family member is similar to a Drosophila protein that plays a key role in the Hedgehog signaling pathway. This human protein is a positive regulator of the GLI zinc-finger transcription factors. Knockout studies of the homologous mouse gene suggest that defects in this human gene may lead to congenital hydrocephalus, possibly due to a functional defect in motile cilia. Because Hedgehog signaling is frequently activated in certain kinds of gastrointestinal cancers, it has been suggested that this gene is a target for the treatment of these cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]