Signal Transducing Adaptor Molecule 2 Recombinant Protein | STAM2 recombinant protein

Recombinant Signal Transducing Adaptor Molecule 2 (STAM2)

Cat. Num. AAA2032951

• Gene Names: STAM2; Hbp; STAM2A; STAM2B
• Applications: SDS-Page, Western Blot, ELISA, Immunoprecipitation
• Purity: > 90%
• Synonyms: Signal Transducing Adaptor Molecule 2; Recombinant Signal Transducing Adaptor Molecule 2 (STAM2); Hbp; STAM2A; STAM2B; SH3 Domain And ITAM Motif; Hrs-binding protein; STAM2 recombinant protein

• Host: E Coli
• Purity/Purification: > 90%
• Form/Format: Supplied as lyophilized form in 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5% trehalose, and preservative.
• Sequence: MPLFTANPFE QDVEKATNEY NTTEDWSLIM DICDRVGSTP NGAKDCLKAI MKRVNHKVPH VALQALTLLG ACVANCGKIF HLEVCSRDFA TEVRAVIKNK AHPKVCEKLK SLMVEWSEEF QKDPQFSLIS ATIKAMKEEG VTFPSAGSQT VSAAAKNGAS LNKNKEDEDI AKAIELSLQE QKQQYPETKA LCPPAESQLS NKVARRVRAL YDFEAVEDNE LTFKHGEIIT VLDDSDANWW EGENHRGAGL FPSSFVTTDL STEVEAATVD KSNVIDDDVE EIKKSEPEPV YIDEGKMDRA LQILQSIDPK DPKPDSQDLL DLEDICQQMG PMIDEKLEEI DRRHSELSEL NVKVLEALELYNKLVNEAPM YSVYSKL
• Sequence Length: 525

• Applicable Applications for STAM2 recombinant protein: SDS-PAGE, Western (WB), ELISA (EIA), Immunoprecipitation (IP).
• Predicted Molecular Mass: 72.2kDa
• Usage: Reconstitute in sterile PBS, pH7.2-pH7.4.
• Endotoxin Level: <1.0EU per 1 ug (determined by the LAL method)
• Expression System: Prokaryotic expression
• Fragment: Met1~Leu377
• Organism Species: Rat
• Tag: two N-terminal Tags, His-tag and GST-tag
• Preparation and Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.; Stability Test: The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.

SDS-Page

NCBI and Uniprot Product Information

• NCBI GI #: 119631897
• NCBI GeneID: 10254
• Molecular Weight: 38,370 Da
• NCBI Official Full Name: signal transducing adaptor molecule (SH3 domain and ITAM motif) 2, isoform CRA_a
• NCBI Official Synonym Full Names: signal transducing adaptor molecule 2
• NCBI Official Symbol: STAM2
• NCBI Official Synonym Symbols: Hbp; STAM2A; STAM2B
• NCBI Protein Information: signal transducing adapter molecule 2
• UniProt Protein Name: Signal transducing adapter molecule 2
• Protein Family: Signal transducing adapter molecule
• UniProt Gene Name: STAM2
• UniProt Synonym Gene Names: HBP; STAM-2
• UniProt Entry Name: STAM2_HUMAN

NCBI Description

The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation. [provided by RefSeq, Jul 2008]

Uniprot Description

STAM2: an adaptor protein involved in the downstream signaling of cytokine receptors. Contain a SH3 domain and immunoreceptor tyrosine-based activation motif (ITAM). Acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. May modulate the signaling pathway downstream of JAK kinases upon cytokine stimulation.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2q23.3

Cellular Component: cytoplasm; cytosol; early endosome membrane; intracellular membrane-bound organelle; nucleoplasm

Molecular Function: protein binding

Biological Process: autophagy; endosome transport; epidermal growth factor receptor signaling pathway; intracellular protein transport; negative regulation of epidermal growth factor receptor signaling pathway