Mouse Sterol Regulatory Element Binding Proteins ELISA Kit | SREBP elisa kit
Mouse Sterol Regulatory Element Binding Proteins ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the a ubiquitously expressed transcription factor that controls cholesterol homeostasis by regulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain and binds the sterol regulatory element 1 motif. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Uniprot Description
SREBP-2: Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway. Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes. Belongs to the SREBP family.
Protein type: Membrane protein, integral; DNA-binding; Transcription factor; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 22q13
Cellular Component: Golgi membrane; nucleoplasm; endoplasmic reticulum membrane; endoplasmic reticulum; cytoplasm; nucleolus; cytosol; nucleus
Molecular Function: protein dimerization activity; protein C-terminus binding; protein binding; C-8 sterol isomerase activity
Biological Process: cholesterol metabolic process; transcription, DNA-dependent; response to low density lipoprotein stimulus; positive regulation of transcription from RNA polymerase II promoter; cellular lipid metabolic process; lipid metabolic process; negative regulation of transcription from RNA polymerase II promoter
Research Articles on SREBP
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Product Notes
The Mouse SREBP srebf2 (Catalog #AAA040597) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA040597 ELISA Kit recognizes Mouse SREBP. It is sometimes possible for the material contained within the vial of "Sterol Regulatory Element Binding Proteins, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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