Sterol regulatory element-binding protein 1 (Srebf1) Recombinant Protein | Srebf1 recombinant protein
Recombinant Rat Sterol regulatory element-binding protein 1 (Srebf1)
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
NCBI and Uniprot Product Information
NCBI Description
transcription factor; binds to the sterol regulatory element 1; regulates the transcription of genes important for sterol biosynthesis [RGD, Feb 2006]
Uniprot Description
SREBP-1: Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). Forms a tight complex with SCAP in the ER membrane. Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein. Interacts with LMNA. Expressed in a wide variety of tissues, most abundant in liver and adrenal gland. In fetal tissues lung and liver shows highest expression. Isoform SREBP-1C predominates in liver, adrenal gland and ovary, whereas isoform SREBP-1A predominates in hepatoma cell lines. Isoform SREBP-1A and isoform SREBP-1C are found in kidney, brain, white fat, and muscle. Belongs to the SREBP family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; DNA-binding; Transcription factor; Membrane protein, integral
Cellular Component: cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi membrane; integral to membrane; intracellular membrane-bound organelle; membrane; nucleus; protein complex
Molecular Function: chromatin binding; DNA binding; protein complex binding; protein dimerization activity; protein kinase binding; sequence-specific DNA binding; sterol response element binding; transcription factor activity
Biological Process: aging; cellular response to insulin stimulus; cellular response to starvation; chemical signal regulation of heart rate; cholesterol metabolic process; circadian rhythm; fat cell differentiation; insulin receptor signaling pathway; lipid biosynthetic process; lung development; mRNA transcription from RNA polymerase II promoter; negative regulation of insulin secretion; negative regulation of transcription from RNA polymerase II promoter; positive regulation of cholesterol biosynthetic process; positive regulation of histone deacetylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of fatty acid metabolic process; regulation of insulin secretion; regulation of protein stability; regulation of transcription, DNA-dependent; response to cAMP; response to drug; response to food; response to glucagon stimulus; response to glucose stimulus; response to insulin stimulus; response to lipid; response to organic cyclic substance; response to peptide hormone stimulus; response to progesterone stimulus; response to retinoic acid
Research Articles on Srebf1
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Product Notes
The Srebf1 srebf1 (Catalog #AAA7030453) is a Recombinant Protein produced from Cell Free Expression and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-480aa; Full length protein. This is a recombinant transmembrane protein expressed in a cell-free expression system. Researchers should empirically determine the suitability of the Srebf1 srebf1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MDELPFGEAA LEQALAEVCE MDAALLTDIE DMLQLINNQD SDFPGLFDAP YAGGETGDTG PSSPGASSPE SFSSPASLGS SLEAFLGGPK VTPAPLSPPP SAPTAVKMYP SVPPFSPGPG IKEEPVPLTI LQPPAPQPSP GTLLPPSFPP PPVQLSPAPV LGYSSLPSGF SGTLPGNTQQ TPSSLPLGST PGISPTPLHT QVQSSAAQQP PPASAAPRMS TVASQIQQVP VVLQPHFIKA DSLLLTAVKT DTGATMKTAG INTLAPGTAV QAGPLQTLVS GGTILATVPL VVDTDKLPIH RLAAGGKALG SAQSRGEKRT AHNAIEKRYR SSINDKIVEL KDLVVGTEAK LNKSAVLRKA IDYIRFLQHS NQKLKQENLT LRSAHKSKSL KDLVSACGSG GGTDVSMEGM KPEVVETLTP PPSDAGSPSQ SSPLSLGSRG SSSGGSDSEP DSPAFEDNQV KAQRLPSHSR GMLDRSRLAL. It is sometimes possible for the material contained within the vial of "Sterol regulatory element-binding protein 1 (Srebf1), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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