Mouse sprouty-related, EVH1 domain containing 1 ELISA Kit | SPRED1 elisa kit
Mouse Sprouty-related, EVH1 domain-containing protein 1, SPRED1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a membrane-associated protein that is phosphorylated by tyrosine kinases in response to growth factors. The encoded protein acts as a negative regulator of the mitogen-activated protein (MAP) kinase signaling pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
Uniprot Description
SPRED1: Tyrosine kinase substrate that inhibits growth-factor- mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow. Defects in SPRED1 are the cause of neurofibromatosis type 1-like syndrome (NFLS). It is a disorder characterized mainly by cafe au lait macules without neurofibromas or other tumor manifestations of neurofibromatosis type 1, axillary freckling, and macrocephaly. Additional clinical manifestations include Noonan-like facial dysmorphism, lipomas, learning disabilities and attention deficit-hyperactivity.
Protein type: Inhibitor
Cellular Component: nucleoplasm; membrane; cytoplasm; plasma membrane; nucleus
Molecular Function: protein serine/threonine kinase inhibitor activity; protein binding; stem cell factor receptor binding; protein kinase binding; phosphatase binding
Biological Process: multicellular organismal development; regulation of signal transduction; positive regulation of DNA damage response, signal transduction by p53 class mediator; inactivation of MAPK activity
Research Articles on SPRED1
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Product Notes
The Mouse SPRED1 spred1 (Catalog #AAA9329776) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9329776 ELISA Kit recognizes Mouse SPRED1. It is sometimes possible for the material contained within the vial of "sprouty-related, EVH1 domain containing 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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