Serine protease inhibitor Kazal-type 5 (SPINK5) Recombinant Protein | SPINK5 recombinant protein
Recombinant Human Serine protease inhibitor Kazal-type 5 (SPINK5) , partial
or antimicrobial protection of mucous epithelia. Mutations may result in Netherton syndrome, a disorder characterized by ichthyosis, defective cornification, and atopy. Multiple transcript variants encoding different isoforms have been found for this gene.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a multidomain serine protease inhibitor that contains 15 potential inhibitory domains. The encoded preproprotein is proteolytically processed to generate multiple protein products, which may exhibit unique activities and specificities. These proteins may play a role in skin and hair morphogenesis, as well as anti-inflammatory and antimicrobial protection of mucous epithelia. Mutations in this gene may result in Netherton syndrome, a disorder characterized by ichthyosis, defective cornification, and atopy. This gene is present in a gene cluster on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Uniprot Description
Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense-activating and desquamation-involved proteases. Inhibits KLK5, it's major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin.
Research Articles on SPINK5
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Product Notes
The SPINK5 spink5 (Catalog #AAA1368957) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 490-759. Partial, provide the Kazal-like 8-11 domain (D8-D11). The amino acid sequence is listed below: EAAKEICSEF RDQVRNGTLI CTREHNPVRG PDGKMHGNKC AMCASVFKLE EEEKKNDKEE KGKVEAEKVK REAVQELCSE YRHYVRNGRL PCTRENDPIE GLDGKIHGNT CSMCEAFFQQ EAKEKERAEP RAKVKREAEK ETCDEFRRLL QNGKLFCTRE NDPVRGPDGK THGNKCAMCK AVFQKENEER KRKEEEDQRN AAGHGSSGGG GGNTQDECAE YREQMKNGRL SCTRESDPVR DADGKSYNNQ CTMCKAKLER EAERKNEYSR . It is sometimes possible for the material contained within the vial of "Serine protease inhibitor Kazal-type 5 (SPINK5), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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