Protein Spindly (Ccdc99) Recombinant Protein | Ccdc99 recombinant protein

Recombinant Mouse Protein Spindly (Ccdc99)

Gene Names

Spdl1; Ccdc99; AA409762; 1700018I02Rik; 2600001J17Rik; 2810049B11Rik

Purity

Greater or equal to 85% purity as determined by SDS-PAGE.

Synonyms

Protein Spindly (Ccdc99); Recombinant Mouse Protein Spindly (Ccdc99); Ccdc99 recombinant protein

Ordering
Cat. Num. AAA1284152 When autocomplete results are available use up and down arrows to review and enter to select. Touch device users, explore by touch or with swipe gestures. For Research Use Only!

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE.

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Sequence Positions

1-608, Full length protein

Sequence

MEADITNLRNKLKECEDERLKAAHYGLQLLERQTELQSQLDKCHEEMMITAEKYNQEKHALQREVELKSRMLDSLSCECEALKQQQKAQLEQLEVQLHRSHRQEVSDLKNKLENLKVELDEARLGEKQLKQKLDLQGELLAHKSEELRLLSEQRVLSSMSSELLALETELTAAEGVKNALKEEVNELQYKQEQLECLNTSLLHQVDRLKEEKEEREREAVSYYNALEKARVENQDLQVQLGHALQQAADPNSKGNSLFAEVEDRRVAMERQLNLMKDKYQSLKKQNAFTRDQMNKMKLQISTLLRMRGSQTEFEQQERLFAMIEQKNGEIKHLLGEINKLEKFKNLYESMESRPSTSDTACVLEDSTYYSDLLQLKLDKLNKENESTKDELSIQRMKALFESQRALDIERKLFTNERHLQLSESENMKLRAKLDELKLKYEPEERIEVPVLKRRREVLPLNITTPEETEETAAASATEDGVSRLPPHREEESCLNSLKDNTVQWKQPASSCVQPASLSPHKNLHLDTQPKKEKKCVKLVDSPANIEVLHEQSGNTPNSPRLTAESKLPTEVKERIETTSKLGKGACKKSHNIIYVSSKSAPETQCSQQ

Sequence Length

608

Species

Mouse

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

NCBI GI #

160333332

NCBI GeneID

70385

NCBI Accession #

NP_081687.2

NCBI GenBank Nucleotide #

NM_027411.2

UniProt Accession #

Q923A2; Q5DY45

Molecular Weight

70,237 Da

NCBI Official Full Name

protein Spindly

NCBI Official Synonym Full Names

spindle apparatus coiled-coil protein 1

NCBI Official Symbol

Spdl1

NCBI Official Synonym Symbols

Ccdc99; AA409762; 1700018I02Rik; 2600001J17Rik; 2810049B11Rik

NCBI Protein Information

protein Spindly

UniProt Protein Name

Protein Spindly

UniProt Gene Name

Spdl1

UniProt Synonym Gene Names

Ccdc99

Uniprot Description

Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) ().

Research Articles on Ccdc99

1. Overexpression of mSpindly failed to enhance inactivation of SAC and acceleration of the meiotic process.

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Product Notes

The Ccdc99 spdl1 (Catalog #AAA1284152) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-608, Full length protein. The amino acid sequence is listed below: MEADITNLRN KLKECEDERL KAAHYGLQLL ERQTELQSQL DKCHEEMMIT AEKYNQEKHA LQREVELKSR MLDSLSCECE ALKQQQKAQL EQLEVQLHRS HRQEVSDLKN KLENLKVELD EARLGEKQLK QKLDLQGELL AHKSEELRLL SEQRVLSSMS SELLALETEL TAAEGVKNAL KEEVNELQYK QEQLECLNTS LLHQVDRLKE EKEEREREAV SYYNALEKAR VENQDLQVQL GHALQQAADP NSKGNSLFAE VEDRRVAMER QLNLMKDKYQ SLKKQNAFTR DQMNKMKLQI STLLRMRGSQ TEFEQQERLF AMIEQKNGEI KHLLGEINKL EKFKNLYESM ESRPSTSDTA CVLEDSTYYS DLLQLKLDKL NKENESTKDE LSIQRMKALF ESQRALDIER KLFTNERHLQ LSESENMKLR AKLDELKLKY EPEERIEVPV LKRRREVLPL NITTPEETEE TAAASATEDG VSRLPPHREE ESCLNSLKDN TVQWKQPASS CVQPASLSPH KNLHLDTQPK KEKKCVKLVD SPANIEVLHE QSGNTPNSPR LTAESKLPTE VKERIETTSK LGKGACKKSH NIIYVSSKSA PETQCSQQ. It is sometimes possible for the material contained within the vial of "Protein Spindly (Ccdc99), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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