Spastin (spas) Recombinant Protein | DgriGH18484 recombinant protein
Recombinant Drosophila grimshawi Spastin (spas)
NCBI and Uniprot Product Information
Uniprot Description
Function: ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse
By similarity. HAMAP-Rule MF_03021
Catalytic activity: ATP + H2O = ADP + phosphate. HAMAP-Rule MF_03021
Subunit structure: Homohexamer. The homohexamer is stabilized by ATP-binding. The homohexamer may adopt a ring conformation through which microtubules pass prior to being severed. Interacts with microtubules
By similarity.
Subcellular location: Membrane; Single-pass membrane protein
Potential. Cytoplasm › cytoskeleton › centrosome
By similarity. Cytoplasm › cytoskeleton
By similarity. Chromosome
By similarity. Note: Colocalizes with cellular microtubule arrays. Localizes to chromosomes from prometaphase/metaphase to anaphase, and this requires microtubules. Localizes to discrete punctate cytoplasmic foci which may correspond to secretory vesicles
By similarity. HAMAP-Rule MF_03021
Sequence similarities: Belongs to the AAA ATPase family. Spastin subfamily.Contains 1 MIT domain.
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Product Notes
The DgriGH18484 spas (Catalog #AAA1148638) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-782. The amino acid sequence is listed below: MVRTKNQSSS SSASSSTKSP VKISGGTTNR SRSCSDALID DGNSKSSSKP TSNNRQRTTT NNNTTAITTT PGSSPDNDDD DTTTTDADLT PTSGNAPRGG NSSVHKQNLY VVSFPIIFLF NVLRSLIYQL FCIFRYLYGA STKVIYRSPN RRDCNIEIVV QNSKEQQQQH QHQQAIIHCP LERRGNISGI EQTLAQALPQ RQRAIQPLEM AGNRAGGNYS PGPGDPLLAK QKHHHRRAFE YISKALKIDE ENEGHKELAI ELYRKGIKEL EDGIAVDCWS GRGDVWDRAQ RLHDKMQTNL SMARDRLHFL ALREEDLQLQ RLSLKEQQQK KKSPQQQPQQ QQQHTFKQPM LVGQTNSSGG SGSTKVPLRS SGYGLKPSAT NISRAMPAAS GRKLTIGNKR PGNLPVVNKS QTLPRNLGSK TSSTSVGAAL QRQPGKTAAT PPAVRRQFSS GRNTPPQRSR TPINNNAAGG SGSGASTPMV SVKGVEQKLV QLILDEIVEG GAKVEWTDIA GQDVAKQALQ EMVILPSVRP ELFTGLRAPA KGLLLFGPPG NGKTLLARAV ATECSATFLN ISAASLTSKY VGDGEKLVRA LFAVARHMQP SIIFIDEVDS LLSERSSNEH EASRRLKTEF LVEFDGLPGN PDGDRIVVLA ATNRPQELDE AALRRFTKRV YVSLPDVQTR ELLLNRLLQK QGSPLDSDAL GRLAKITEGY SGSDLTALAK DAALEPIREL NVEQVKCLDI SAMRQITEKD FHNSLKRIRR SVAPQSLNSY EKWSQDYGDI TI. It is sometimes possible for the material contained within the vial of "Spastin (spas), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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