Sex Determining Region Y Box Protein 7 Recombinant Protein | SOX7 recombinant protein

Recombinant Sex Determining Region Y Box Protein 7 (SOX7)

Cat. Num. AAA2123752

• Applications: SDS-Page, Western Blot
• Purity: >90%
• Synonyms: Sex Determining Region Y Box Protein 7; Recombinant Sex Determining Region Y Box Protein 7 (SOX7); Transcription factor SOX-7; SOX7 recombinant protein

• Host: E Coli
• Purity/Purification: >90%
• Form/Format: Freeze-dried powder; PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Sequence Positions: Gln217~Ser388
• Sequence Length: 388

• Applicable Applications for SOX7 recombinant protein: Positive Control, Immunogen, SDS-PAGE, Western Blot (WB)
• Source: Prokaryotic expression
• Species: Human
• Tag: N-terminal His Tag
• Subcellular Location: Secreted
• Isoelectric Point: 5.3
• Reconstitution: Reconstitute in PBS or others.
• Preparation and Storage: Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. Avoid repeated freeze/thaw cycles.; Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Product Categories/Family for SOX7 recombinant protein

Reproductive science

NCBI and Uniprot Product Information

• NCBI GI #: 20532272
• NCBI GeneID: 83595
• UniProt Accession #: Q9BT81
• Molecular Weight: Predicted Molecular Mass: 22kDa; Accurate Molecular Mass: 25kDa
• NCBI Official Full Name: Transcription factor SOX-7
• NCBI Official Synonym Full Names: SRY-box transcription factor 7
• NCBI Official Symbol: SOX7
• NCBI Protein Information: transcription factor SOX-7
• UniProt Protein Name: Transcription factor SOX-7
• Protein Family: Transcription factor
• UniProt Gene Name: SOX7
• UniProt Entry Name: SOX7_HUMAN

NCBI Description

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may play a role in tumorigenesis. A similar protein in mice is involved in the regulation of the wingless-type MMTV integration site family (Wnt) pathway. [provided by RefSeq, Jul 2008]

Uniprot Description

SOX7: Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors. May be required for the survival of both hematopoietic and endothelial precursors during specification. Competes with GATA4 for binding and activation of the FGF3 promoter. Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'- AACAAT-3'.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 8p23.1

Cellular Component: cytoplasm; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding; transcription factor activity

Biological Process: regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; negative regulation of cell proliferation; endoderm formation; positive regulation of transcription, DNA-dependent; positive regulation of caspase activity; negative regulation of transcription, DNA-dependent