Human sorbin and SH3 domain containing 3 ELISA Kit | SORBS3 elisa kit
Human Vinexin, SORBS3 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an SH3 domain-containing adaptor protein. The presence of SH3 domains play a role in this protein's ability to bind other cytoplasmic molecules and contribute to cystoskeletal organization, cell adhesion and migration, signaling, and gene expression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Uniprot Description
vinexin: an adapter protein that contains three SH3 domains and is involved in the reorganization of actin cytoskeleton. Two alternatively spliced isoforms have been described. Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain. Both isoforms localize at focal adhesion and cell-cell adhesion sites; vinexin beta was also found in the nucleus. Interacts with DLG5 through its third SH3 domain. Interacts with vinculin by the first two SH3 domains and the proline rich region of vinculin. Binds to SOS (guanine nucleotide exchange factor of RAS and RAC) through its third SH3 domain. The formation of this complex is down-regulated by phosphorylation of SOS. Interacts with SAFB2.
Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold; Cell adhesion; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 8p21.3
Cellular Component: focal adhesion; cytoskeleton; nucleus; cytosol
Molecular Function: protein binding; structural constituent of cytoskeleton; transcription factor binding; vinculin binding
Biological Process: positive regulation of MAPKKK cascade; muscle contraction; positive regulation of stress fiber formation; actin filament organization; positive regulation of cytoskeleton organization and biogenesis; negative regulation of transcription from RNA polymerase II promoter; cell adhesion; cell-substrate adhesion
Research Articles on SORBS3
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Product Notes
The Human SORBS3 sorbs3 (Catalog #AAA9319867) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9319867 ELISA Kit recognizes Human SORBS3. It is sometimes possible for the material contained within the vial of "sorbin and SH3 domain containing 3, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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