Protein SON (SON) Recombinant Protein | SON recombinant protein

Recombinant Human Protein SON (SON) , partial

• Gene Names: SON; SON3; BASS1; DBP-5; NREBP; TOKIMS; C21orf50
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Protein SON (SON); Recombinant Human Protein SON (SON); partial; SON recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 2,282

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for SON recombinant protein

This protein binds to a specific DNA sequence upstream of the upstream regulatory sequence of the core promoter and second enhancer of human hepatitis B virus (HBV). Through this binding, it represses HBV core promoter activity, transcription of HBV genes, and production of HBV virions. The protein shows sequence similarities with other DNA-binding structural proteins such as gallin, oncoproteins of the MYC family, and the oncoprotein MOS. It may also be involved in protecting cells from apoptosis and in pre-mRNA splicing. Several transcript variants encoding different isoforms have been described for this gene, but the full-length nature of only two of them has been determined.

NCBI and Uniprot Product Information

• NCBI GI #: 609876591
• NCBI GeneID: 6651
• NCBI Accession #: NP_001278340.1
• NCBI GenBank Nucleotide #: NM_001291411.1
• UniProt Accession #: P18583; O14487; O95981; Q14120; Q6PKE0; Q9H7B1; D3DSF5; D3DSF6; E7ETE8; E7EU67; E7EVW3; E9PFQ2
• Molecular Weight: 247,823 Da
• NCBI Official Full Name: protein SON isoform E
• NCBI Official Synonym Full Names: SON DNA binding protein
• NCBI Official Symbol: SON
• NCBI Official Synonym Symbols: SON3; BASS1; DBP-5; NREBP; TOKIMS; C21orf50
• NCBI Protein Information: protein SON
• UniProt Protein Name: Protein SON
• Protein Family: Protein
• UniProt Gene Name: SON
• UniProt Synonym Gene Names: C21orf50; DBP5; KIAA1019; NREBP; BASS1; NRE-binding protein

NCBI Description

This gene encodes a protein that contains multiple simple repeats. The encoded protein binds RNA and promotes pre-mRNA splicing, particularly of transcripts with poor splice sites. The protein also recognizes a specific DNA sequence found in the human hepatitis B virus (HBV) and represses HBV core promoter activity. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Uniprot Description

RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680).