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Synuclein Alpha (SNCa) Recombinant Protein | SNCa recombinant protein
Recombinant Synuclein Alpha (SNCa)
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NCBI and Uniprot Product Information
Accurate Molecular Weight: 17kDa
NCBI Description
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
Uniprot Description
SNCA: a member of the synuclein family that is abundantly expressed in the brain. Inhibits phospholipase D2 selectively. May integrate presynaptic signaling and membrane trafficking. Aggregated forms of the protein are implicated in the pathogenesis of Parkinson's disease. A major component of amyloid plaques in the brains of patients with Alzheimer's disease. Three alternatively spliced human isoforms have been identified.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 4q22.1
Cellular Component: actin cytoskeleton; axon; cell cortex; cell junction; cell soma; cytoplasm; cytosol; extracellular region; extracellular space; Golgi apparatus; growth cone; inclusion body; lysosome; membrane; mitochondrial respiratory chain complex I; mitochondrion; nuclear outer membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; platelet alpha granule membrane; postsynapse; ribosome; rough endoplasmic reticulum; synaptic vesicle; terminal bouton
Molecular Function: alpha-tubulin binding; beta-tubulin binding; calcium ion binding; caspase inhibitor activity; copper ion binding; fatty acid binding; ferrous iron binding; histone binding; Hsp70 protein binding; identical protein binding; kinesin binding; magnesium ion binding; microtubule binding; oxidoreductase activity; phospholipase binding; phospholipid binding; phosphoprotein binding; protein binding; protein domain specific binding; protein N-terminus binding; tau protein binding; transcription regulatory region DNA binding; zinc ion binding
Biological Process: activation of cysteine-type endopeptidase activity involved in apoptotic process; adult locomotory behavior; aging; apoptosis; behavioral response to cocaine; calcium ion homeostasis; cellular protein metabolic process; cellular response to copper ion; cellular response to epinephrine stimulus; cellular response to fibroblast growth factor stimulus; cellular response to oxidative stress; dopamine biosynthetic process; dopamine uptake; excitatory postsynaptic potential; fatty acid metabolic process; microglial cell activation; mitochondrial membrane organization and biogenesis; negative regulation of apoptosis; negative regulation of chaperone-mediated autophagy; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of dopamine metabolic process; negative regulation of dopamine uptake involved in synaptic transmission; negative regulation of exocytosis; negative regulation of histone acetylation; negative regulation of microtubule polymerization; negative regulation of monooxygenase activity; negative regulation of neuron apoptosis; negative regulation of neuron death; negative regulation of norepinephrine uptake; negative regulation of platelet-derived growth factor receptor signaling pathway; negative regulation of protein phosphorylation; negative regulation of serotonin uptake; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transporter activity; neutral lipid metabolic process; organelle ATP synthesis coupled electron transport; phospholipid metabolic process; positive regulation of apoptosis; positive regulation of endocytosis; positive regulation of inflammatory response; positive regulation of neuron death; positive regulation of neurotransmitter secretion; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein serine/threonine kinase activity; positive regulation of receptor recycling; positive regulation of release of sequestered calcium ion into cytosol; protein destabilization; receptor internalization; regulation of acyl-CoA biosynthetic process; regulation of dopamine secretion; regulation of glutamate secretion; regulation of locomotion; regulation of long-term neuronal synaptic plasticity; regulation of macrophage activation; regulation of phospholipase activity; regulation of presynapse assembly; response to drug; response to iron(II) ion; response to lipopolysaccharide; response to magnesium ion; synapse organization; synaptic vesicle endocytosis
Disease: Dementia, Lewy Body; Parkinson Disease 1, Autosomal Dominant; Parkinson Disease 4, Autosomal Dominant
Research Articles on SNCa
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Product Notes
The SNCa snca (Catalog #AAA2097570) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Recombinant Synuclein Alpha (SNCa) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Synuclein Alpha (SNCa) can be used in a range of immunoassay formats including, but not limited to, Positive Control, Immunogen, SDS-PAGE, Western Blot (WB). Researchers should empirically determine the suitability of the SNCa snca for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Synuclein Alpha (SNCa), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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