Russells Viper Venom Factor V Activator Protease | SVSP protease
Russells Viper Venom Factor V Activator
NCBI and Uniprot Product Information
Uniprot Description
Function: Venom serine protease that activates factor V (F5) in a calcium-independent manner. It cleaves the Arg(1545)-Ser(1546) linkage in the human factor V molecule. Induces the coagulation of mammalian plasma. Ref.1 Ref.2
Catalytic activity: Fully activates human clotting factor V by a single cleavage at the 1545-Trp-Tyr-Leu-Arg-|-Ser-Asn-Asn-Gly-1552 bond. Cattle, but not rabbit, factor V is cleaved, and no other proteins of the clotting system are attacked. Esterase activity is observed on Bz-Arg-OEt and Tos-Arg-OMe, and amidase activity on Phe-pipecolyl-Arg-NHPhNO2.
Enzyme regulation: Inhibited by D-Phe-Pro-Arg-chloromethyl ketone (FPRCK) (97%), PMSF (76%), and benzamidine (50%). Is not inhibited by BPTI, antithrombin and EDTA. Ref.2
Subunit structure: Monomer.
Subcellular location: Secreted.
Tissue specificity: Expressed by the venom gland.
Miscellaneous: There are three isoproteins of RVV-V, designated RVV-V alpha, V-beta, and V-gamma.Has no proteolytic effect on factor VIII, factor XIII, fibrinogen, and prothrombin (Ref.2).
Sequence similarities: Belongs to the peptidase S1 family. Snake venom subfamily.Contains 1 peptidase S1 domain.
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Product Notes
The SVSP rvv-v alpha (Catalog #AAA135607) is a Protease produced from Snake venom and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Russells Viper Venom Factor V Activator, Protease" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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