Smoothened homolog (SMO) Recombinant Protein | SMO recombinant protein
Recombinant Human Smoothened homolog (SMO)
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex. [provided by RefSeq, Jul 2010]
Uniprot Description
SMO: G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia. Belongs to the G-protein coupled receptor Fz/Smo family.
Protein type: Receptor, GPCR; GPCR, Fz/Smo family; Cell development/differentiation; Oncoprotein; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 7q32.3
Cellular Component: caveola; Golgi apparatus; integral to membrane; intracellular membrane-bound organelle; plasma membrane
Molecular Function: drug binding; G-protein coupled receptor activity; patched binding; protein binding; Wnt receptor activity; Wnt-protein binding
Biological Process: activation of hh target transcription factor; anterior/posterior pattern formation; astrocyte activation; cell fate specification; central nervous system neuron differentiation; cerebellar cortex morphogenesis; cerebral cortex development; dentate gyrus development; dorsoventral neural tube patterning; forebrain morphogenesis; G-protein coupled receptor protein signaling pathway; hair follicle morphogenesis; heart looping; homeostasis of number of cells within a tissue; in utero embryonic development; midgut development; multicellular organism growth; myoblast migration; negative regulation of apoptosis; negative regulation of DNA binding; negative regulation of epithelial cell differentiation; negative regulation of hair follicle development; negative regulation of transcription from RNA polymerase II promoter; neural crest cell migration; odontogenesis of dentine-containing teeth; osteoblast differentiation; positive regulation of epithelial cell proliferation; positive regulation of mesenchymal cell proliferation; positive regulation of multicellular organism growth; positive regulation of neuroblast proliferation; positive regulation of organ growth; positive regulation of protein import into nucleus; positive regulation of smoothened signaling pathway; positive regulation of transcription from RNA polymerase II promoter; protein stabilization; skeletal muscle fiber development; smoothened signaling pathway; smoothened signaling pathway in regulation of granule cell precursor cell proliferation; smoothened signaling pathway in ventral spinal cord patterning; thalamus development; vasculogenesis; ventral midline determination; Wnt receptor signaling pathway through beta-catenin
Research Articles on SMO
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Product Notes
The SMO smo (Catalog #AAA7030169) is a Recombinant Protein produced from Cell Free Expression and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 28-787aa; full length protein. This is a recombinant transmembrane protein expressed in a cell-free expression system. Researchers should empirically determine the suitability of the SMO smo for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: RGAASSGNAT GPGPRSAGGS ARRSAAVTGP PPPLSHCGRA APCEPLRYNV CLGSVLPYGA TSTLLAGDSD SQEEAHGKLV LWSGLRNAPR CWAVIQPLLC AVYMPKCEND RVELPSRTLC QATRGPCAIV ERERGWPDFL RCTPDRFPEG CTNEVQNIKF NSSGQCEVPL VRTDNPKSWY EDVEGCGIQC QNPLFTEAEH QDMHSYIAAF GAVTGLCTLF TLATFVADWR NSNRYPAVIL FYVNACFFVG SIGWLAQFMD GARREIVCRA DGTMRLGEPT SNETLSCVII FVIVYYALMA GVVWFVVLTY AWHTSFKALG TTYQPLSGKT SYFHLLTWSL PFVLTVAILA VAQVDGDSVS GICFVGYKNY RYRAGFVLAP IGLVLIVGGY FLIRGVMTLF SIKSNHPGLL SEKAASKINE TMLRLGIFGF LAFGFVLITF SCHFYDFFNQ AEWERSFRDY VLCQANVTIG LPTKQPIPDC EIKNRPSLLV EKINLFAMFG TGIAMSTWVW TKATLLIWRR TWCRLTGQSD DEPKRIKKSK MIAKAFSKRH ELLQNPGQEL SFSMHTVSHD GPVAGLAFDL NEPSADVSSA WAQHVTKMVA RRGAILPQDI SVTPVATPVP PEEQANLWLV EAEISPELQK RLGRKKKRRK RKKEVCPLAP PPELHPPAPA PSTIPRLPQL PRQKCLVAAG AWGAGDSCRQ GAWTLVSNPF CPEPSPPQDP FLPSAPAPVA WAHGRRQGLG PIHSRTNLMD TELMDADSDF. It is sometimes possible for the material contained within the vial of "Smoothened homolog (SMO), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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