Rat Smoothened homolog ELISA Kit | Smo elisa kit
Rat Smoothened homolog ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
may act as a signaling component of the Patched (Ptch) signaling pathway [RGD, Feb 2006]
Uniprot Description
SMO: G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia. Belongs to the G-protein coupled receptor Fz/Smo family.
Protein type: Cell development/differentiation; GPCR, Fz/Smo family; Membrane protein, integral; Membrane protein, multi-pass; Oncoprotein; Receptor, GPCR
Chromosomal Location of Human Ortholog: 4q22
Cellular Component: caveola; cell soma; cilium; cytoplasm; dendrite; Golgi apparatus; integral to membrane; intracellular membrane-bound organelle; nucleus; plasma membrane; postsynaptic density
Molecular Function: drug binding; G-protein coupled receptor activity; patched binding; Wnt receptor activity; Wnt-protein binding
Biological Process: activation of hh target transcription factor; anterior/posterior pattern formation; astrocyte activation; axon extension involved in axon guidance; cell development; cell fate specification; central nervous system development; central nervous system neuron differentiation; cerebellar cortex morphogenesis; cerebral cortex development; dentate gyrus development; determination of left/right symmetry; developmental growth; dorsal/ventral pattern formation; dorsoventral neural tube patterning; embryonic organ development; facial nerve development; forebrain morphogenesis; gut development; hair follicle morphogenesis; heart looping; heart morphogenesis; homeostasis of number of cells within a tissue; in utero embryonic development; midgut development; multicellular organism growth; myoblast migration; negative regulation of apoptosis; negative regulation of DNA binding; negative regulation of epithelial cell differentiation; negative regulation of hair follicle development; negative regulation of neuron apoptosis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; neural crest cell migration; neurite regeneration; odontogenesis of dentine-containing teeth; ossification; osteoblast differentiation; osteoblast proliferation; pattern specification process; positive regulation of cell proliferation; positive regulation of epithelial cell proliferation; positive regulation of mesenchymal cell proliferation; positive regulation of multicellular organism growth; positive regulation of neuroblast proliferation; positive regulation of organ growth; positive regulation of protein import into nucleus; positive regulation of smoothened signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein stabilization; regulation of gene expression; response to organic substance; response to wounding; skeletal muscle fiber development; smoothened signaling pathway; smoothened signaling pathway in regulation of granule cell precursor cell proliferation; smoothened signaling pathway in ventral spinal cord patterning; spermatogenesis; thalamus development; vasculogenesis; ventral midline determination; Wnt receptor signaling pathway through beta-catenin
Research Articles on Smo
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Product Notes
The Rat Smo smo (Catalog #AAA9427546) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9427546 ELISA Kit recognizes Rat Smo. It is sometimes possible for the material contained within the vial of "Smoothened homolog, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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