Smith-Magenis syndrome chromosomal region candidate gene 8 protein homolog (Smcr8) Recombinant Protein | Smcr8 recombinant protein

Recombinant Mouse Smith-Magenis syndrome chromosomal region candidate gene 8 protein homolog (Smcr8) , partial

• Gene Names: Smcr8; AI642055; 2310076G09Rik; D030073L15Rik
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Smith-Magenis syndrome chromosomal region candidate gene 8 protein homolog (Smcr8); Recombinant Mouse Smith-Magenis syndrome chromosomal region candidate gene 8 protein homolog (Smcr8); partial; Smcr8 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 785

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 146198710
• NCBI GeneID: 237782
• NCBI Accession #: NP_001078909.1
• NCBI GenBank Nucleotide #: NM_001085440.1
• UniProt Accession #: Q3UMB5; Q5U4H2; Q8BNG6; Q8C704
• Molecular Weight: 87,709 Da
• NCBI Official Full Name: guanine nucleotide exchange protein SMCR8 isoform 1
• NCBI Official Synonym Full Names: Smith-Magenis syndrome chromosome region, candidate 8 homolog (human)
• NCBI Official Symbol: Smcr8
• NCBI Official Synonym Symbols: AI642055; 2310076G09Rik; D030073L15Rik
• NCBI Protein Information: guanine nucleotide exchange protein SMCR8
• UniProt Protein Name: Guanine nucleotide exchange protein SMCR8
• Protein Family: Smith-Magenis syndrome chromosomal region candidate gene 8 protein
• UniProt Gene Name: Smcr8

Uniprot Description

Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:27617292). In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity (PubMed:27617292). Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates (). In addition to its activity in the cytoplasm within the C9orf72-SMCR8 complex, SMCR8 also localizes in the nucleus, where it associates with chromatin and negatively regulates expression of suppresses ULK1 and WIPI2 genes ().