Human structural maintenance of chromosomes 6 ELISA Kit | SMC6 elisa kit
Human Structural maintenance of chromosomes protein 6, SMC6 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
SMC6L1: Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Belongs to the SMC family. SMC6 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA repair, damage
Chromosomal Location of Human Ortholog: 2p24.2
Cellular Component: nucleoplasm; chromosome, telomeric region; PML body; nucleolus; intracellular; nucleus
Molecular Function: protein binding; ATP binding
Biological Process: telomere maintenance via recombination; double-strand break repair via homologous recombination
Research Articles on SMC6
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Product Notes
The Human SMC6 smc6 (Catalog #AAA9327976) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9327976 ELISA Kit recognizes Human SMC6. It is sometimes possible for the material contained within the vial of "structural maintenance of chromosomes 6, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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