Structural maintenance of chromosomes protein 1A (Smc1a) Recombinant Protein | Smc1a recombinant protein

Recombinant Mouse Structural maintenance of chromosomes protein 1A (Smc1a) , partial

• Gene Names: Smc1a; Smc1; Smcb; Sb1.8; SMC-1A; Smc1l1; Smc1alpha; mKIAA0178; 5830426I24Rik
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Structural maintenance of chromosomes protein 1A (Smc1a); Recombinant Mouse Structural maintenance of chromosomes protein 1A (Smc1a); partial; Smc1a recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1,233

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Smc1a recombinant protein

Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or This protein. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation.

NCBI and Uniprot Product Information

• NCBI GI #: 258613892
• NCBI GeneID: 24061
• NCBI Accession #: NP_062684.2
• NCBI GenBank Nucleotide #: NM_019710.2
• UniProt Accession #: Q9CU62; Q3V480; Q9CUX9; Q9D959; Q9WTU1; A2AFQ5
• Molecular Weight: 143,235 Da
• NCBI Official Full Name: structural maintenance of chromosomes protein 1A
• NCBI Official Synonym Full Names: structural maintenance of chromosomes 1A
• NCBI Official Symbol: Smc1a
• NCBI Official Synonym Symbols: Smc1; Smcb; Sb1.8; SMC-1A; Smc1l1; Smc1alpha; mKIAA0178; 5830426I24Rik
• NCBI Protein Information: structural maintenance of chromosomes protein 1A
• UniProt Protein Name: Structural maintenance of chromosomes protein 1A
• Protein Family: Structural maintenance of chromosomes protein
• UniProt Gene Name: Smc1a
• UniProt Synonym Gene Names: Sb1.8; Smc1; Smc1l1; Smcb; SMC protein 1A; SMC-1-alpha; SMC-1A

Uniprot Description

Involved in chromosome cohesion during cell cycle and in DNA repair. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, and works as a downstream effector in the ATM/NBS1 branch of S-phase checkpoint (). Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.