Mouse SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 ELISA Kit | SMARCE1 elisa kit
Mouse SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1, SMARCE1 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
SMARCE1: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Required for the coactivation of estrogen responsive promoters by Swi/Snf complexes and the SRC/p160 family of histone acetyltransferases (HATs). Also specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Defects in SMARCE1 may be a cause of Coffin-Siris syndrome, a highly variable disease characterized by mental retardation associated with a broad spectrum of different clinical features. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Cellular Component: nucleoplasm; SWI/SNF complex; protein complex; transcriptional repressor complex; nuclear chromatin; nucleus
Molecular Function: ligand-dependent nuclear receptor binding; protein binding; N-acetyltransferase activity; nucleosomal DNA binding; DNA binding; RNA binding; protein N-terminus binding; chromatin binding
Biological Process: chromatin remodeling; nervous system development; regulation of transcription, DNA-dependent; nucleosome disassembly; metabolic process; ATP-dependent chromatin remodeling; chromatin modification; negative regulation of transcription, DNA-dependent
Research Articles on SMARCE1
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Product Notes
The Mouse SMARCE1 smarce1 (Catalog #AAA9339949) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9339949 ELISA Kit recognizes Mouse SMARCE1. It is sometimes possible for the material contained within the vial of "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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