Structure-specific endonuclease subunit SLX4 (Slx4) Recombinant Protein | Slx4 recombinant protein

Recombinant Mouse Structure-specific endonuclease subunit SLX4 (Slx4) , partial

• Gene Names: Slx4; Btbd12; AI256635; AI426760; D16Bwg1016e
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Structure-specific endonuclease subunit SLX4 (Slx4); Recombinant Mouse Structure-specific endonuclease subunit SLX4 (Slx4); partial; Slx4 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1,565

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 42734487
• NCBI GeneID: 52864
• NCBI Accession #: NP_803423.2
• NCBI GenBank Nucleotide #: NM_177472.5
• UniProt Accession #: Q6P1D7
• Molecular Weight: 172,412 Da
• NCBI Official Full Name: structure-specific endonuclease subunit SLX4
• NCBI Official Synonym Full Names: SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)
• NCBI Official Symbol: Slx4
• NCBI Official Synonym Symbols: Btbd12; AI256635; AI426760; D16Bwg1016e
• NCBI Protein Information: structure-specific endonuclease subunit SLX4
• UniProt Protein Name: Structure-specific endonuclease subunit SLX4
• Protein Family: Structure-specific endonuclease
• UniProt Gene Name: Slx4
• UniProt Synonym Gene Names: Btbd12

NCBI Description

This gene encodes a protein containing a BTB (POZ) domain that comprises a subunit of structure-specific endonucleases. The encoded protein aids in the resolution of DNA secondary structures that arise during the processes of DNA repair and recombination. Knock out of this gene in mouse recapitulates the phenotype of the human disease Fanconi anemia, including blood cytopenia and susceptibility to genomic instability. [provided by RefSeq, Dec 2013]

Uniprot Description

Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks ().