Phosphatidylinositol:ceramide inositolphosphotransferase (SLS1) Recombinant Protein | SLS1 recombinant protein
Recombinant Phosphatidylinositol:ceramide inositolphosphotransferase (SLS1)
NCBI and Uniprot Product Information
Uniprot Description
Function: Bidirectional lipid inositolphosphotransferase capable of converting phosphatidylinositol (PI) and ceramide to inositol-phosphorylceramide (IPC) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relative concentrations of DAG and ceramide as phosphoinositol acceptors. Essential for viability of the pathogenic bloodstream stage of this human protozoan parasite and, consequently, can be considered as potential drug target. Ref.1 Ref.2
Subcellular location: Membrane; Multi-pass membrane protein
Potential.
Developmental stage: Found only in procyclic parasites. Ref.1
Disruption phenotype: Elevated ceramide levels and growth arrest; cells were arrested in division but replication of DNA and organelles continued giving rise to cells containing multiple nuclei, kinetoplasts and flagella. Ref.1
Sequence similarities: Belongs to the sphingomyelin synthase family.
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Product Notes
The Phosphatidylinositol:ceramide inositolphosphotransferase (SLS1) sls1 (Catalog #AAA1119649) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-355. The amino acid sequence is listed below: MISYPFFSLS PPGLVPPPMA VPPVEMYSGS FWNRMRKPLP LRTQVIRFTV VFVIVSFILA VALQITHERM PDPKVTKPLP DLGFELLTKI SFLSVVTDVL IAFLSLLSFF TLWKLYLLHR HCVGSGEPEL PCNIPGVSRF FLSVWLCKEN CRIELRNIHT IAWIRFITSY ALLLLFRSLV IVMTSMPTPV DKCQDPPKIE NPVKNVILTV LTAGGGSIHC GDLMVSGHTV ILTLHLMFHW IYGAMVHWSF RPVVTVVAIF SYYCIVASRS HYTDDVLVAI YLTIATFIAV GHNADGAPWQ LQLFIRWLPC CGANSREVTE DSQPVMVAFK SEAVDELRER DDSAGLSGEV STNEV. It is sometimes possible for the material contained within the vial of "Phosphatidylinositol:ceramide inositolphosphotransferase (SLS1), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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