Uniprot Description
Mediates the exchange of one Ca2+ ion against three to four Na+ ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca2+ levels and Ca2+-dependent cellular processes. Contributes to Ca2+ transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca2+ levels due to release of Ca2+ stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca2+ from the cell during the next phase, so that cytoplasmic Ca2+ levels rapidly return to baseline. Required for normal embryonic heart development and the onset of heart contractions.
Product Notes
The SLC8A1 slc8a1 (Catalog #
AAA965017) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 33-970. The amino acid sequence is listed below: DTEMEGEGNE TGECTGSYYC KKGVILPIWE PQDPSFGDKI ARATVYFVAM VYMFLGVSII ADRFMSSIEV ITSQEKEITI KKPNGETTKT TVRIWNETVS NLTLMALGSS APEILLSVIE VCGHNFTAGD LGPSTIVGSA AFNMFIIIAL CVYVVPDGET RKIKHLRVFF VTAAWSIFAY TWLYIILSVI SPGVVEVWEG LLTFFFFPIC VVFAWVADRR LLFYKYVYKR YRAGKQRGMI IEHEGDRPSS KTEIEMDGKV VNSHVDNFLD GALVLEVDER DQDDEEARRE MARILKELKQ KHPEKEIEQL IELANYQVLS QQQKSRAFYR IQATRLMTGA GNILKRHAAD QARKAVSMHE VNTEVAENDP VSKIFFEQGT YQCLENCGTV ALTILRRGGD LTNTVFVDFR TEDGTANAGS DYEFTEGTVV FKPGETQKEI RVGIIDDDIF EEDENFLVHL SNVKVSSEAS EDGILEANHV STLACLGSPS TATVTIFDDD HAGIFTFEEP VTHVSESIGI MEVKVLRTSG ARGNVIVPYK TIEGTARGGG EDFEDTCGEL EFQNDEIVKT ISVKVIDDEE YEKNKTFFLE IGEPRLVEMS EKKALLLNEL GGFTITGKYL YGQPVFRKVH AREHPIPSTV ITIAEECDAK QPLTSKEEEE RRIAEMGRPI LGEHTKLEVI IEESYEFKST VDKLIKKTNL ALVVGTNSWR EQFIEAITVS AGEDDDDDEC GEEKLPSCFD YVMHFLTVFW KVLFAFVPPT EYWNGWACFI VSILMIGILT AFIGDLASHF GCTIGLKDSV TAVVFVALGT SVPDTFASKV AATQDQYADA SIGNVTGSNA VNVFLGIGVA WSIAAIYHAA NGEQFKVSPG TLAFSVTLFT IFAFINVGVL LYRRRPEIGG ELGGPRTAKL LTSCLFVLLW LLYIFFSSLE AYCHIKGF.
It is sometimes possible for the material contained within the vial of
"Sodium/calcium exchanger 1 (SLC8A1), Recombinant Protein" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
required.
Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are
absolutely not suitable for use in any
sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a
product from AAA Biotech, you
are explicitly certifying that said products will be properly tested and used in line with
industry standard. AAA Biotech
and its authorized distribution partners reserve the right to refuse to fulfill any order if
we have any indication that a
purchaser may be intending to use a product outside of our accepted criteria.
Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech
cannot be held
responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any
aspect of this datasheet at
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of any product performance
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