SLC5A2 recombinant protein

Recombinant Human SLC5A2 protein, C-His Tag

Cat. Num. AAA1560113

• Gene Names: SLC5A2; SGLT2
• Purity: >90% as determined by SDS-PAGE
• Synonyms: SLC5A2; Recombinant Human SLC5A2 protein; C-His Tag; Na (+) /glucose cotransporter 2; Low affinity sodium-glucose cotransporter; Solute carrier family 5 member 2; SGLT2; SLC5A2 recombinant protein

• Host: Mammalian cells
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from PBS pH 7.4, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Source: Human
• Reconstitution: Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
• Construction: A DNA sequence encoding the Human SLC5A2 (Ser335-Leu423) was fused with the C-terminal His Tag
• Preparation and Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for ~12 months from the date of receipt.; Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.; In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise

Product Categories/Family for SLC5A2 recombinant protein

Protein

NCBI and Uniprot Product Information

• NCBI GI #: 4507033
• NCBI GeneID: 6524
• NCBI Accession #: NP_003032.1
• NCBI GenBank Nucleotide #: NM_003041.3
• UniProt Accession #: P31639
• Molecular Weight: 72,897 Da
• NCBI Official Full Name: sodium/glucose cotransporter 2
• NCBI Official Synonym Full Names: solute carrier family 5 (sodium/glucose cotransporter), member 2
• NCBI Official Symbol: SLC5A2
• NCBI Official Synonym Symbols: SGLT2
• NCBI Protein Information: sodium/glucose cotransporter 2; Na(+)/glucose cotransporter 2; solute carrier family 5 member 2; low affinity sodium-glucose cotransporter; solute carrier family 5 (sodium/glucose transporter), member 2
• UniProt Protein Name: Sodium/glucose cotransporter 2
• Protein Family: Sodium/glucose cotransporter
• UniProt Gene Name: SLC5A2
• UniProt Synonym Gene Names: SGLT2; Na(+)/glucose cotransporter 2
• UniProt Entry Name: SC5A2_HUMAN

NCBI Description

This gene encodes a member of the sodium glucose cotransporter family which are sodium-dependent glucose transport proteins. The encoded protein is the major cotransporter involved in glucose reabsorption in the kidney. Mutations in this gene are associated with renal glucosuria. [provided by RefSeq, Sep 2009]

Uniprot Description

SLC5A2: Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1:1. Defects in SLC5A2 are the cause of renal glucosuria (GLYS1). GLYS1 is an autosomal recessive disorder characterized by a normal fasting serum glucose concentration and persistent isolated glucosuria, with a normal glucose tolerance test. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.

Protein type: Membrane protein, integral; Transporter, SLC family; Transporter; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: plasma membrane; integral to membrane

Molecular Function: low-affinity glucose:sodium symporter activity

Biological Process: transport; sodium ion transport; carbohydrate metabolic process; glucose transport; transmembrane transport

Disease: Renal Glucosuria