SLC27A4/FATP4 Recombinant Protein | SLC27A4 recombinant protein

SLC27A4/FATP4 Protein, Human, Recombinant (His Tag)

Cat. Num. AAA8121559

• Gene Names: SLC27A4; IPS; FATP4; ACSVL4
• Purity: >85% as determined by SDS-PAGE
• Synonyms: SLC27A4/FATP4; SLC27A4/FATP4 Protein; Human; Recombinant (His Tag); Human SLC27A4/FATP4 Protein (His Tag); ACSVL4 Protein; FATP4 Protein; IPS Protein; solute carrier family 27 (fatty acid transporter); member 4; SLC27A4 recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >85% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Gln483-Leu643

• Species: Human
• Endotoxin: <1.0EU per ug of the protein as determined by the LAL method
• Predicted N Terminal: His
• Tag: N-His
• Protein Construction: A DNA sequence encoding the human SLC27A4 (NP_005085.2)(Gln483-Leu643) was expressed with a N-terminal polyhistidine tag.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

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Related Product Information for SLC27A4 recombinant protein

Background: SLC27A4/ATG4B complex might act as a new potential therapeutic target of lung tumor chemotherapy. The solute carrier 27A (SLC27A) gene family encodes fatty acid transport proteins (FATPs) and includes 6 members. Autism spectrum disorders (ASD) are now recognized as disorders caused by impaired early brain development, it is possible that functional abnormalities of SLC27A genes may contribute to the pathogenesis of ASD. The expression of SLC27A3 and SLC27A4 in human neural stem cells derived from human induced pluripotent stem cells, which suggested their involvement in the developmental stage of the central nervous system.

NCBI and Uniprot Product Information

• NCBI GI #: 40807357
• NCBI GeneID: 10999
• NCBI Accession #: NP_005085.2
• NCBI GenBank Nucleotide #: NM_005094.3
• UniProt Accession #: Q6P1M0; O95186; A8K2F7
• Molecular Weight: 72,064 Da
• NCBI Official Full Name: long-chain fatty acid transport protein 4
• NCBI Official Synonym Full Names: solute carrier family 27 (fatty acid transporter), member 4
• NCBI Official Symbol: SLC27A4
• NCBI Official Synonym Symbols: IPS; FATP4; ACSVL4
• NCBI Protein Information: long-chain fatty acid transport protein 4
• UniProt Protein Name: Long-chain fatty acid transport protein 4
• Protein Family: Long-chain fatty acid transport protein
• UniProt Gene Name: SLC27A4
• UniProt Synonym Gene Names: ACSVL4; FATP4; FATP-4
• UniProt Entry Name: S27A4_HUMAN

NCBI Description

This gene encodes a member of a family of fatty acid transport proteins, which are involved in translocation of long-chain fatty acids cross the plasma membrane. This protein is expressed at high levels on the apical side of mature enterocytes in the small intestine, and appears to be the principal fatty acid transporter in enterocytes. Clinical studies suggest this gene as a candidate gene for the insulin resistance syndrome. Mutations in this gene have been associated with ichthyosis prematurity syndrome. [provided by RefSeq, Apr 2010]

Uniprot Description

SLC27A4: Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. Defects in SLC27A4 are the cause of ichthyosis prematurity syndrome (IPS). A keratinization disorder characterized by complications in the second trimester of pregnancy resulting from polyhydramnion, with premature birth of a child with thick caseous desquamating epidermis, respiratory complications and transient eosinophilia. After recovery during the first months of life, the symptoms are relatively benign and the patients suffer from a lifelong non-scaly ichthyosis with atopic manifestations. Belongs to the ATP-dependent AMP-binding enzyme family.

Protein type: Membrane protein, multi-pass; Transporter; Membrane protein, integral; Transporter, SLC family; EC 6.2.1.-; Ligase

Chromosomal Location of Human Ortholog: 9q34.11

Cellular Component: endoplasmic reticulum membrane; microvillus; membrane; brush border membrane; integral to membrane; plasma membrane

Molecular Function: fatty acid transporter activity; nucleotide binding; very-long-chain-fatty-acid-CoA ligase activity; long-chain-fatty-acid-CoA ligase activity

Biological Process: long-chain fatty acid transport; skin development; transport; very-long-chain fatty acid catabolic process; long-chain fatty acid metabolic process; lipid metabolic process; medium-chain fatty acid transport; transmembrane transport; fatty acid transport; response to nutrient

Disease: Ichthyosis Prematurity Syndrome