Human solute carrier family 25, member 38 ELISA Kit | SLC25A38 elisa kit
Human Solute carrier family 25 member 38, SLC25A38 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the mitochondrial carrier family. The encoded protein is required during erythropoiesis and is important for the biosynthesis of heme. Mutations in this gene are the cause of autosomal congenital sideroblastic anemia.[provided by RefSeq, Mar 2010]
Uniprot Description
SLC25A38: Mitochondrial carrier required during erythropoiesis. Probably involved in the biosynthesis of heme, possibly by facilitating 5-aminolevulinate (ALA) production. May act by importing glycine into mitochondria or by exchanging glycine for ALA across the mitochondrial inner membrane. Defects in SLC25A38 are a cause of anemia sideroblastic pyridoxine-refractory autosomal recessive (PRARSA). A form of sideroblastic anemia not responsive to pyridoxine. Sideroblastic anemia is characterized by anemia of varying severity, hypochromic peripheral erythrocytes, systemic iron overload secondary to chronic ineffective erythropoiesis, and the presence of bone marrow ringed sideroblasts. Sideroblasts are characterized by iron-loaded mitochondria clustered around the nucleus. Belongs to the mitochondrial carrier family. SLC25A38 subfamily.
Protein type: Transporter; Membrane protein, multi-pass; Transporter, SLC family; Membrane protein, integral; Mitochondrial
Chromosomal Location of Human Ortholog: 3p22.1
Cellular Component: mitochondrial inner membrane; integral to membrane
Biological Process: transport; erythrocyte differentiation; heme biosynthetic process
Disease: Anemia, Sideroblastic, Pyridoxine-refractory, Autosomal Recessive
Research Articles on SLC25A38
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Product Notes
The Human SLC25A38 slc25a38 (Catalog #AAA9337327) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9337327 ELISA Kit recognizes Human SLC25A38. It is sometimes possible for the material contained within the vial of "solute carrier family 25, member 38, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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