Rat solute carrier family 22 (organic cation/carnitine transporter) , member 5 ELISA Kit | SLC22A5 elisa kit
Rat Solute carrier family 22 member 5, SLC22A5 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
mediates high-affinity sodium-dependent carnitine transport and sodium-independent organic cation transport [RGD, Feb 2006]
Uniprot Description
SLC22A5: Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3. Defects in SLC22A5 are the cause of systemic primary carnitine deficiency (CDSP). CDSP is an autosomal recessive disorder of fatty acid oxidation caused by defective carnitine transport. Present early in life with hypoketotic hypoglycemia and acute metabolic decompensation, or later in life with skeletal myopathy or cardiomyopathy. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter; Membrane protein, integral; Membrane protein, multi-pass; Transporter, SLC family
Cellular Component: mitochondrion; basolateral plasma membrane; brush border membrane; apical plasma membrane; integral to membrane
Molecular Function: protein binding; cation:cation antiporter activity; antibiotic transporter activity; symporter activity; carnitine transporter activity; quaternary ammonium group transmembrane transporter activity; ATP binding; PDZ domain binding
Biological Process: adult heart development; mitochondrion organization and biogenesis; organic cation transport; quaternary ammonium group transport; triacylglycerol metabolic process; antibiotic transport; sodium ion transport; locomotory behavior; carnitine metabolic process; reproductive structure development; carnitine transport; quorum sensing during interaction with host
Research Articles on SLC22A5
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Product Notes
The Rat SLC22A5 slc22a5 (Catalog #AAA9321489) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9321489 ELISA Kit recognizes Rat SLC22A5. It is sometimes possible for the material contained within the vial of "solute carrier family 22 (organic cation/carnitine transporter) , member 5, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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