Mouse solute carrier family 22 (organic cation/ergothioneine transporter) , member 4 ELISA Kit | SLC22A4 elisa kit
Mouse Solute carrier family 22 member 4, SLC22A4 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
SLC22A4: Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. A key substrate of this transporter seems to be ergothioneine (ET). Genetic variations in SLC22A4 are a cause of susceptibility to rheumatoid arthritis (RA). It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Protein type: Mitochondrial; Transporter; Membrane protein, integral; Membrane protein, multi-pass; Transporter, SLC family
Cellular Component: membrane; mitochondrion; apical plasma membrane; integral to membrane
Molecular Function: cation:cation antiporter activity; transporter activity; symporter activity; ion transmembrane transporter activity; nucleotide binding; carnitine transporter activity; organic cation transmembrane transporter activity; transmembrane transporter activity; quaternary ammonium group transmembrane transporter activity; ATP binding; PDZ domain binding
Biological Process: organic cation transport; quaternary ammonium group transport; triacylglycerol metabolic process; transport; sodium ion transport; carnitine metabolic process; ion transport; transmembrane transport; carnitine transport
Research Articles on SLC22A4
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Product Notes
The Mouse SLC22A4 slc22a4 (Catalog #AAA9334406) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9334406 ELISA Kit recognizes Mouse SLC22A4. It is sometimes possible for the material contained within the vial of "solute carrier family 22 (organic cation/ergothioneine transporter) , member 4, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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