Human solute carrier family 17 (sodium phosphate) , member 3 ELISA Kit | SLC17A3 elisa kit
Human Sodium-dependent phosphate transport protein 4, SLC17A3 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a voltage-driven transporter that excretes intracellular urate and organic anions from the blood into renal tubule cells. Two transcript variants encoding different isoforms have been found for this gene. The longer isoform is a plasma membrane protein with transporter activity while the shorter isoform localizes to the endoplasmic reticulum. [provided by RefSeq, Aug 2012]
Uniprot Description
SLC17A3: Isoform 2: voltage-driven, multispecific, organic anion transporter able to transport para-aminohippurate (PAH), estrone sulfate, estradiol-17-beta-glucuronide, bumetanide, and ochratoxin A. Isoform 2 functions as urate efflux transporter on the apical side of renal proximal tubule and is likely to act as an exit path for organic anionic drugs as well as urate in vivo. May be involved in actively transporting phosphate into cells via Na(+) cotransport. Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter, SLC family; Transporter; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 6p21.3
Cellular Component: endoplasmic reticulum membrane; perinuclear region of cytoplasm; integral to plasma membrane; brush border membrane; cytoplasm; apical plasma membrane; plasma membrane
Molecular Function: efflux transmembrane transporter activity; organic anion transmembrane transporter activity; toxin transporter activity; voltage-gated anion channel activity; urate transmembrane transporter activity; drug transporter activity; sodium:phosphate symporter activity
Biological Process: urate transport; urate metabolic process; phosphate transport; drug transport; glucose-6-phosphate transport; sodium ion transport; multidrug transport; organic acid transport; transmembrane transport; organic anion transport
Disease: Uric Acid Concentration, Serum, Quantitative Trait Locus 4
Research Articles on SLC17A3
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Product Notes
The Human SLC17A3 slc17a3 (Catalog #AAA9340816) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9340816 ELISA Kit recognizes Human SLC17A3. It is sometimes possible for the material contained within the vial of "solute carrier family 17 (sodium phosphate) , member 3, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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