Rat solute carrier family 16, member 2 (monocarboxylic acid transporter 8) ELISA Kit | SLC16A2 elisa kit
Rat Monocarboxylate transporter 8, SLC16A2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
human homolog is a monocarboxylate transporter [RGD, Feb 2006]
Uniprot Description
SLC16A2: Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr. Defects in SLC16A2 are the cause of monocarboxylate transporter 8 deficiency (MCT8 deficiency); also known as Allan-Herndon-Dudley syndrome (AHDS). MCT8 deficiency consists of a severe form of X-linked psychomotor retardation combined with abnormal thyroid hormone (TH) levels. Thyroid hormone deficiency can be caused by defects of hormone synthesis and action, but it has also been linked to a defect in cellular hormone transport. Affected patients are males with abnormal relative concentrations of three circulating iodothyronines, as well as severe neurological abnormalities, including global developmental delay, central hypotonia, spastic quadriplegia, dystonic movements, rotary nystagmus, and impaired gaze and hearing. Heterozygous females had a milder thyroid phenotype and no neurological defects. Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
Protein type: Transporter, SLC family; Membrane protein, integral; Membrane protein, multi-pass; Transporter
Cellular Component: integral to membrane; plasma membrane
Molecular Function: thyroid hormone transmembrane transporter activity; symporter activity
Biological Process: hormone transport; transmembrane transport
Research Articles on SLC16A2
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Product Notes
The Rat SLC16A2 slc16a2 (Catalog #AAA9317526) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9317526 ELISA Kit recognizes Rat SLC16A2. It is sometimes possible for the material contained within the vial of "solute carrier family 16, member 2 (monocarboxylic acid transporter 8), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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