Human SIX homeobox 2 ELISA Kit | SIX2 elisa kit

Human Homeobox protein SIX2, SIX2 ELISA Kit

Cat. Num. AAA9324676

• Reactivity: Human
• Synonyms: SIX homeobox 2; Human Homeobox protein SIX2; SIX2 ELISA Kit; Human Homeobox protein SIX2 (SIX2) ELISA kit; sine oculis homeobox homolog 2; SIX2 elisa kit

• Reactivity: Human

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 219275578
• NCBI GeneID: 10736
• NCBI Accession #: NP_058628.3
• NCBI GenBank Nucleotide #: NM_016932.4
• UniProt Accession #: Q9NPC8; Q9BXH7
• Molecular Weight: 32,286 Da
• NCBI Official Full Name: homeobox protein SIX2
• NCBI Official Synonym Full Names: SIX homeobox 2
• NCBI Official Symbol: SIX2
• NCBI Protein Information: homeobox protein SIX2; sine oculis homeobox homolog 2
• UniProt Protein Name: Homeobox protein SIX2
• Protein Family: Homeobox protein
• UniProt Gene Name: SIX2
• UniProt Entry Name: SIX2_HUMAN

NCBI Description

This gene is a member of the vertebrate gene family which encode proteins homologous to the Drosophila 'sine oculis' homeobox protein. The encoded protein is a transcription factor which, like other members of this gene family, may be involved in limb or eye development. [provided by RefSeq, Dec 2008]

Uniprot Description

SIX2: Transcription factor that plays an important role in the development of several organs, including kidney, skull and stomach. During kidney development, maintains cap mesenchyme multipotent nephron progenitor cells in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud and cooperates with WNT9B to promote renewing progenitor cells proliferation. Acts through its interaction with TCF7L2 and OSR1 in a canonical Wnt signaling independent manner preventing transcription of differentiation genes in cap mesenchyme such as WNT4. Also acts independently of OSR1 to activate expression of many cap mesenchyme genes, including itself, GDNF and OSR1. During craniofacial development plays a role in growth and elongation of the cranial base through regulation of chondrocyte differentiation. During stomach organogenesis, controls pyloric sphincter formation and mucosal growth through regulation of a gene network including NKX2-5, BMPR1B, BMP4, SOX9 and GREM1. During branchial arch development, acts to mediate HOXA2 control over the insulin-like growth factor pathway. Also may be involved in limb tendon and ligament development. Plays a role in cell proliferation and migration. {ECO:0000250|UniProtKB:Q62232, ECO:0000269|PubMed:22995329}. Belongs to the SIX/Sine oculis homeobox family. {ECO:0000305}. Interacts with TCF7L2; in a canonical Wnt signaling independent manner; prevents transcription of differentiation genes in cap mesenchyme. Interacts with OSR1; form a strong repressor complex with TCF7L2, TLE2 and TLE3 to prevent the activation of Wnt/beta-catenin target genes in the cap mesenchyme. Interacts with HOXA11, EYA1 and EYA3. {ECO:0000250|UniProtKB:Q62232}

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 2p21

Cellular Component: nucleoplasm; nuclear membrane; cytoplasm; plasma membrane; nucleus

Molecular Function: sequence-specific DNA binding; protein complex binding; transcription factor binding; transcription factor activity

Biological Process: anatomical structure morphogenesis; cell migration; embryonic cranial skeleton morphogenesis; middle ear morphogenesis; cell proliferation; protein import into nucleus; embryonic digestive tract morphogenesis; mesodermal cell fate specification; chondrocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of chondrocyte differentiation; kidney development; regulation of ossification; anterior/posterior axis specification