NAD-dependent protein deacetylase sirtuin-7 (Sirt7) Recombinant Protein | Sirt7 recombinant protein

Recombinant Mouse NAD-dependent protein deacetylase sirtuin-7 (Sirt7)

Cat. Num. AAA1289655

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: NAD-dependent protein deacetylase sirtuin-7 (Sirt7); Recombinant Mouse NAD-dependent protein deacetylase sirtuin-7 (Sirt7); Sirt7 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-402, full length protein
• Sequence: MAAGGGLSRSERKAAERVRRLREEQQRERLRQVSRILRKAAAERSAEEGRLLAESEDLVTELQGRSRRREGLKRRQEEVCDDPEELRRKVRELAGAVRSARHLVVYTGAGISTAASIPDYRGPNGVWTLLQKGRPVSAADLSEAEPTLTHMSITRLHEQKLVQHVVSQNCDGLHLRSGLPRTAISELHGNMYIEVCTSCIPNREYVRVFDVTERTALHRHLTGRTCHKCGTQLRDTIVHFGERGTLGQPLNWEAATEAASKADTILCLGSSLKVLKKYPRLWCMTKPPSRRPKLYIVNLQWTPKDDWAALKLHGKCDDVMQLLMNELGLEIPVYNRWQDPIFSLATPLRAGEEGSHSRKSLCRSREEAPPGDQSDPLASAPPILGGWFGRGCAKRAKRKKVA
• Sequence Length: 402

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Sirt7 recombinant protein

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. This protein is included in class IV of the sirtuin family.

NCBI and Uniprot Product Information

• NCBI GI #: 165932356
• NCBI GeneID: 209011
• NCBI Accession #: NP_694696.2
• NCBI GenBank Nucleotide #: NM_153056.2
• UniProt Accession #: Q8BKJ9; Q6X7B7; Q8QZZ5; A2ABY7
• Molecular Weight: 45,146 Da
• NCBI Official Full Name: NAD-dependent protein deacetylase sirtuin-7
• NCBI Official Synonym Full Names: sirtuin 7
• NCBI Official Symbol: Sirt7
• NCBI Protein Information: NAD-dependent protein deacetylase sirtuin-7
• UniProt Protein Name: NAD-dependent protein deacetylase sirtuin-7
• Protein Family: NAD-dependent protein deacetylase
• UniProt Gene Name: Sirt7
• UniProt Synonym Gene Names: Sir2l7

Uniprot Description

NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions (). Required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis. Promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex. May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation.