Bovine sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae) ELISA Kit | SIRT4 elisa kit
Bovine NAD-dependent ADP-ribosyltransferase sirtuin-4, SIRT4 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
Function: Acts both as NAD-dependent protein ADP-ribosyl transferase and NAD-dependent protein deacetylase. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Down-regulates insulin secretion UniRule annotationHAMAP-Rule:MF_03161
Catalytic activity: NAD+ + a protein = nicotinamide + an N-(ADP-D-ribosyl)-protein.UniRule annotationHAMAP-Rule:MF_03161
Cofactor: Binds 1 zinc ion per subunit UniRule annotationHAMAP-Rule:MF_03161
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Product Notes
The Bovine SIRT4 sirt4 (Catalog #AAA9316065) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9316065 ELISA Kit recognizes Bovine SIRT4. It is sometimes possible for the material contained within the vial of "sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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