Signal-Regulatory Protein alpha-1/SIRPA/CD172a Recombinant Protein | SIRPA/CD172a recombinant protein
Recombinant Mouse Signal-Regulatory Protein alpha-1/SIRPA/CD172a Protein (C-6His)
Gene Names
Sirpa; Bit; P84; SIRP; SHP-1; CD172a; Ptpns1; SHPS-1; AI835480
Purity
>95% as determined by reducing SDS-PAGE.
Synonyms
Signal-Regulatory Protein alpha-1/SIRPA/CD172a; Recombinant Mouse Signal-Regulatory Protein alpha-1/SIRPA/CD172a Protein (C-6His); Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1; SHP Substrate 1; Brain Ig-Like Molecule with Tyrosine-Based Activation Motifs; CD172 Antigen-Like Family Member A; Inhibitory Feceptor SHPS-1; Macrophage Fusion Receptor; Signal-Regulatory Protein Alpha-1; Sirp-Alpha-1; Signal-Regulatory Protein Alpha-2; Sirp-Alpha-2; Signal-Regulatory Protein Alpha-3; Sirp-Alpha-3; CD172a; SIRPA; MFR; SHPS1; SIRP; SIRPA/CD172a recombinant protein
Host
Human Cells
Purity/Purification
>95% as determined by reducing SDS-PAGE.
Form/Format
Lyophilized from a 0.2 mum filtered solution of PBS, pH 7.4.
Sequence Positions
Lys32-Asn372
Sequence Length
509
Species
Mouse
Endotoxin
<1.0 EU per mug as determined by LAL test.
Fusion Tag
C-6His
Preparation and Storage
Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.
Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.
Related Product Information for SIRPA/CD172a recombinant protein
Mouse Signal Regulatory Protein alpha (SIRPalpha) is a type I transmembrane glycoprotein.It contains two Ig-like C1-type domains and one Ig-like V-type domain. Mouse SIRP alpha ECD shares 61%, 75%, 62%, 61%, and 59% aa sequence identity with human, rat, equine, bovine, and porcine SIRP alpha, respectively.SIRPalpha can express in various tissues, mainly on brain and myeloid cells, including macrophages, neutrophils, dendritic and Langerhans cells. It also can detect in neurons, smooth muscle and endothelial cells. SIRPA is an immunoglobulin-like cell surface receptor for CD47. SIRPalpha acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPalpha shows adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. SIRPalpha engagement generally produces a negative regulatory signal; it may mediate negative regulation of phagocytosis, mast cell activation and dendritic cell activation
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Molecular Mass: 38.7 kDa
Actual Protein Molecular Mass: 60-110 kDa
Actual Protein Molecular Mass: 60-110 kDa
NCBI Official Full Name
tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1
NCBI Official Synonym Full Names
signal-regulatory protein alpha
NCBI Official Symbol
Sirpa
NCBI Official Synonym Symbols
Bit; P84; SIRP; SHP-1; CD172a; Ptpns1; SHPS-1; AI835480
NCBI Protein Information
tyrosine-protein phosphatase non-receptor type substrate 1
UniProt Protein Name
Signal-regulatory protein alpha
UniProt Gene Name
Sirpa
UniProt Synonym Gene Names
Ptpns1ImportedAutomatic assertion inferred from database entriesiMGI:108563
Uniprot Description
Enzyme and pathway databasesReactome - a knowledgebase of biological pathways and processesMore...ReactomeiR-MMU-202733 Cell surface interactions at the vascular wallR-MMU-2172127 DAP12 interactionsR-MMU-391160 Signal regulatory protein family interactionsR-MMU-6798695 Neutrophil degranulation
Research Articles on SIRPA/CD172a
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Product Notes
The SIRPA/CD172a sirpa (Catalog #AAA2553612) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is Lys32-Asn372. It is sometimes possible for the material contained within the vial of "Signal-Regulatory Protein alpha-1/SIRPA/CD172a, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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